A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

Parkinson's disease (PD) is caused by abnormal accumulation of α-synuclein in
dopaminergic neurons of the substantia nigra, which subsequently causes motor symptoms …

The genetic landscape of Parkinson's disease (PD) is characterised by rare high penetrance
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …

Covalent attachment (conjugation) of one or more ubiquitin molecules to protein substrates
governs numerous eukaryotic cellular processes, including apoptosis, cell division and …

Since the first formal description of Parkinson disease (PD) two centuries ago, our
understanding of this common neurodegenerative disorder has expanded at all levels of …

Oxidative stress plays an important role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …

Astrocytes contribute to the maintenance of the health and function of the central nervous
system (CNS). Thus, it is not surprising that these multifunctional cells have been implicated …

Mitophagy is a highly specialized process to remove dysfunctional or superfluous
mitochondria through the macroautophagy/autophagy pathway, aimed at protecting cells …

Septins belong to a family of proteins that is highly conserved in eukaryotes and is
increasingly recognized as a novel component of the cytoskeleton. All septins are GTP …

Mistakes are part of our world and constantly occurring. Due to transcriptional and
translational failures, genomic mutations or diverse stress conditions like oxidation or heat …