RAS family variants—most of which involve KRAS—are the most commonly occurring
hotspot mutations in human cancers and are associated with a poor prognosis. For almost …

Cells rely on the endoplasmic reticulum (ER) to fold and assemble newly synthesized
transmembrane and secretory proteins—essential for cellular structure–function and for both …

The unfolded protein response (UPR) is a mechanism aiming at restoring endoplasmic
reticulum (ER) homeostasis and is likely involved in other adaptive pathways. The UPR is …

Direct targeting of the KRAS-G12C–mutant protein using covalent inhibitors (G12Ci) acts on
human non–small cell lung cancer (NSCLC). However, drug resistance is an emerging …

Eukaryotic cells are equipped with an intricate proteostasis network (PN), comprising nearly
3000 components dedicated to preserving proteome integrity and sustaining protein …

Abstract KRAS G12C mutations in non-small cell lung cancer (NSCLC) partially respond to
KRAS G12C covalent inhibitors. However, early adaptive resistance occurs due to rewiring …

The clinical success of KRAS G12C inhibitors (G12Ci) including AMG510 and MRTX849 is
limited by the eventual development of acquired resistance. A novel and effective treatment …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive solid malignancy with low
5-year survival and limited treatment options. We conducted an unbiased screening using …

Cellular senescence, one of the hallmarks of cancer, is characterized by cell cycle arrest and
the loss of most normal cellular functions while acquiring a hypersecretory, proinflammatory …

The RAS gene family comprises genes that regulate cell growth and differentiation. KRAS, a
member of this family, is often mutated in different cancers, resulting in uncontrolled cell …