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The neuropathobiology of multiple sclerosis
Chronic low-grade inflammation and neuronal deregulation are two components of a
smoldering disease activity that drives the progression of disability in people with multiple …
smoldering disease activity that drives the progression of disability in people with multiple …
Mechanisms of axonal support by oligodendrocyte-derived extracellular vesicles
Extracellular vesicles (EVs) have recently emerged as versatile elements of cell
communication in the nervous system, mediating tissue homeostasis. EVs influence the …
communication in the nervous system, mediating tissue homeostasis. EVs influence the …
Acriflavine, a HIF-1 inhibitor, preserves vision in an experimental autoimmune encephalomyelitis model of optic neuritis
Introduction Optic neuritis (ON) is often an early sign of multiple sclerosis (MS), and recent
studies show a link between HIF-1 pathway activation and inflammation. This study aimed to …
studies show a link between HIF-1 pathway activation and inflammation. This study aimed to …
Developmental maturation and regional heterogeneity but no sexual dimorphism of the murine CNS myelin proteome
SB Siems, VI Gargareta, LC Schadt… - Glia, 2025 - Wiley Online Library
The molecules that constitute myelin are critical for the integrity of axon/myelin‐units and
thus speed and precision of impulse propagation. In the CNS, the protein composition of …
thus speed and precision of impulse propagation. In the CNS, the protein composition of …
Seeking neuroprotection in multiple sclerosis: An ongoing challenge
Multiple sclerosis (MS) is an autoimmune disease of the CNS, featuring inflammation and
demyelination with variable recovery. In this issue of the JCI, Kapell, Fazio, and authors …
demyelination with variable recovery. In this issue of the JCI, Kapell, Fazio, and authors …
Multiple Sclerosis: Glial Cell Diversity in Time and Space
Multiple sclerosis (MS) is the most prevalent human inflammatory disease of the central
nervous system with demyelination and glial scar formation as pathological hallmarks. Glial …
nervous system with demyelination and glial scar formation as pathological hallmarks. Glial …
[HTML][HTML] Retigabine, a potassium channel opener, restores thalamocortical neuron functionality in a murine model of autoimmune encephalomyelitis
Abstract Background Multiple Sclerosis (MS) is an autoimmune neurodegenerative disease,
whose primary hallmark is the occurrence of inflammatory lesions in white and grey matter …
whose primary hallmark is the occurrence of inflammatory lesions in white and grey matter …
Clemastine improves emotional and social deficits in adolescent social isolation mice by reversing demyelination
D Guo, Y Yao, X Liu, Y Han - Pharmacology Biochemistry and Behavior, 2024 - Elsevier
Adolescence is a critical period for social experience-dependent oligodendrocyte maturation
and myelination. Adolescent stress predisposes to cause irreversible changes in brain …
and myelination. Adolescent stress predisposes to cause irreversible changes in brain …
[HTML][HTML] Preclinical Insights into the Role of Kir4. 1 in Chronic Pain and Depression: Mechanisms and Therapeutic Potential
T Zha, X Fang, J Wan, X Chen, J Lin, Q Chen - Biomolecules, 2025 - mdpi.com
Chronic pain and mental health disorders, such as depression and anxiety, frequently co-
occur and share underlying mechanisms involving neuronal excitability and synaptic …
occur and share underlying mechanisms involving neuronal excitability and synaptic …
[HTML][HTML] Dysfunctional K+ Homeostasis as a Driver for Brain Inflammation
The central nervous system (CNS) relies on precise regulation of potassium ion (K+)
concentrations to maintain physiology. This regulation involves complex cellular and …
concentrations to maintain physiology. This regulation involves complex cellular and …