Gastrointestinal cancer represents one of the most diagnosed types of cancer. Cancer is a
genetic and multifactorial disease, influenced by the host and environmental factors. It has …

The rising incidence and persistent dismal 5-year overall survival of pancreatic ductal
adenocarcinoma (PDAC) highlight the need for new effective systemic therapies …

Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …

The steadfast advance of the synthetic biology field has enabled scientists to use genetically
engineered cells, instead of small molecules or biologics, as the basis for the development …

Simple Summary Immunotherapies have revolutionized the field of cancer therapeutics, yet
a substantial subset of patients fail to respond. Recent efforts have focused on identifying …

Immunotherapy has revolutionized the treatment of cancer but continues to be constrained
by limited response rates, acquired resistance, toxicities and high costs, which necessitates …

Pancreatic ductal adenocarcinoma (PDA) is among the most immune-resistant tumor types.
Its unique genomic landscape shaped by oncogenic drivers promotes immune suppression …

Cytokines are soluble proteins that mediate cell-to-cell communication. Based on the
discovery of the potent anti-tumour activities of several pro-inflammatory cytokines in animal …

Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with poor
prognosis and rising incidence. Late detection and a particularly aggressive biology are the …

Microbes with complex functions have been found to be a potential component in tumor
microenvironments. Due to their low biomass and other obstacles, intratumor microbiota is …