CRISPR in cancer biology and therapy
A Katti, BJ Diaz, CM Caragine, NE Sanjana… - Nature Reviews …, 2022 - nature.com
Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …
transforming biomedical research and providing entirely new approaches for dissecting all …
Applications of CRISPR technologies in research and beyond
R Barrangou, JA Doudna - Nature biotechnology, 2016 - nature.com
Programmable DNA cleavage using CRISPR–Cas9 enables efficient, site-specific genome
engineering in single cells and whole organisms. In the research arena, versatile CRISPR …
engineering in single cells and whole organisms. In the research arena, versatile CRISPR …
Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes
S Mueller, T Engleitner, R Maresch, M Zukowska… - Nature, 2018 - nature.com
The poor correlation of mutational landscapes with phenotypes limits our understanding of
the pathogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC). Here we …
the pathogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC). Here we …
Genetically engineered mouse models in oncology research and cancer medicine
K Kersten, KE de Visser, MH van Miltenburg… - EMBO molecular …, 2017 - embopress.org
Genetically engineered mouse models (GEMM s) have contributed significantly to the field of
cancer research. In contrast to cancer cell inoculation models, GEMM s develop de novo …
cancer research. In contrast to cancer cell inoculation models, GEMM s develop de novo …
[HTML][HTML] CRISPR/Cas9 for cancer research and therapy
CRISPR/Cas9 has become a powerful method for making changes to the genome of many
organisms. First discovered in bacteria as part of an adaptive immune system …
organisms. First discovered in bacteria as part of an adaptive immune system …
Preclinical mouse solid tumour models: status quo, challenges and perspectives
N Gengenbacher, M Singhal, HG Augustin - Nature Reviews Cancer, 2017 - nature.com
Oncology research in humans is limited to analytical and observational studies for obvious
ethical reasons, with therapy-focused clinical trials being the one exception to this rule …
ethical reasons, with therapy-focused clinical trials being the one exception to this rule …
[HTML][HTML] Regenerative reprogramming of the intestinal stem cell state via hippo signaling suppresses metastatic colorectal cancer
Although the Hippo transcriptional coactivator YAP is considered oncogenic in many tissues,
its roles in intestinal homeostasis and colorectal cancer (CRC) remain controversial. Here …
its roles in intestinal homeostasis and colorectal cancer (CRC) remain controversial. Here …
Mouse models of metastasis: progress and prospects
L Gómez-Cuadrado, N Tracey, R Ma… - Disease models & …, 2017 - journals.biologists.com
Metastasis is the spread of cancer cells from a primary tumor to distant sites within the body
to establish secondary tumors. Although this is an inefficient process, the consequences are …
to establish secondary tumors. Although this is an inefficient process, the consequences are …
Comprehensive review of CRISPR-based gene editing: mechanisms, challenges, and applications in cancer therapy
M Chehelgerdi, M Chehelgerdi… - Molecular cancer, 2024 - Springer
The CRISPR system is a revolutionary genome editing tool that has the potential to
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …
Tissue-specific tumorigenesis: context matters
G Schneider, M Schmidt-Supprian, R Rad… - Nature Reviews …, 2017 - nature.com
How can we treat cancer more effectively? Traditionally, tumours from the same anatomical
site are treated as one tumour entity. This concept has been challenged by recent …
site are treated as one tumour entity. This concept has been challenged by recent …