The linear ubiquitin chain assembly complex (LUBAC) is a ubiquitin ligase composed of the
Heme-oxidized IRP2 ubiquitin ligase-1L (HOIL-1L), HOIL-1L-interacting protein (HOIP), and …

Receptor interacting protein 1 (RIP1) kinase is a critical regulator of inflammation and cell
death signaling, and plays a crucial role in maintaining immune responses and proper …

Activation of endothelial YAP/TAZ signaling is crucial for physiological and pathological
angiogenesis. The mechanisms of endothelial YAP/TAZ regulation are, however …

The paracaspase mucosa-associated lymphoid tissue 1 (MALT1) is a protease and scaffold
protein essential in propagating B-cell receptor (BCR) signaling to NF-κB. The …

Abstract Receptor Interacting Protein Kinase 1 (RIPK1) is a key regulator of inflammation. To
warrant cell survival and appropriate immune responses, RIPK1 is post-translationally …

Mutations in PINK1 and parkin highlight the mitochondrial axis of Parkinson's disease (PD)
pathogenesis. PINK1/parkin regulation of the transcriptional repressor PARIS bears direct …

Linear ubiquitination is a distinct type of ubiquitination that involves attaching a head-to-tail
polyubiquitin chain to a substrate protein. Early studies found that linear ubiquitin chains are …

Severe acute pancreatitis (SAP) is an acute digestive system disease with high morbidity
mortality and hospitalization rate worldwide, due to various causes and unknown …

Protein–protein interaction (PPI) analysis is a key process to understand protein functions.
Recently, we constructed a human protein array (20 K human protein beads array) …

Abstract Mind bomb 2 (MIB2) is an E3 ligase involved in Notch signalling and attenuates
TNF-induced apoptosis through ubiquitylation of receptor-interacting protein kinase 1 …