The reactive oxygen species (ROS) form under normal physiological conditions and may
have both beneficial and harmful role. We search the literature and current knowledge in the …

Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

Reactive oxygen species (ROS) are generated as by-products of cellular metabolism,
primarily in the mitochondria. Although ROS are essential participants in cell signaling and …

Glaucoma is one of the leading causes of vision impairment worldwide. In order to further
understand the molecular pathobiology of this disease and to develop better therapies …

The retinal ganglion cells (RGCs) are the output cells of the retina into the brain. In
mammals, these cells are not able to regenerate their axons after optic nerve injury, leaving …

Glaucoma is a degenerative optic neuropathy characterized by retinal ganglion cell (RGC)
loss and visual field defects. It is known that in some glaucoma patients, death of RGCs …

Glaucoma is an insidiously progressive optic neuropathy which affects nearly 90 million
people worldwide, and is the leading cause of irreversible blindness. 1–3 It is a …

In adult albino (SD) and pigmented (PVG) rats the entire population of retinal ganglion cells
(RGCs) was quantified and their spatial distribution analyzed using a computerized …

Animal models are useful to elucidate the etiology and pathology of glaucoma and to
develop novel and more effective therapies for the disease. Because of the substantial …

BACKGROUND: Iron is necessary for life, but excess iron can be toxic to tissues. Iron is
thought to damage tissues primarily by generating oxygen free radicals through the Fenton …