The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …

During starvation, fasting, or a diet containing little digestible carbohydrates, the circulating
insulin levels are decreased. This promotes lipolysis, and the breakdown of fat becomes the …

Under normal physiological conditions the brain primarily utilizes glucose for ATP
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …

The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7)
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …

At present, the prevalence of Alzheimer's disease, a devastating neurodegenerative
disorder, is increasing. Although the mechanism of the underlying pathology is not fully …

The ketogenic diet, originally developed for the treatment of epilepsy in non-responder
children, is spreading to be used in the treatment of many diseases, including Alzheimer's …

The ketogenic diet (KD) is a high-fat, low-carbohydrate and adequate-protein diet that has
gained popularity in recent years in the context of neurological diseases (NDs). The …

Impaired mitochondrial function often results in excessive production of reactive oxygen
species (ROS) and is involved in the etiology of many chronic diseases, including …

Alzheimer's disease (AD) is a major cause of dementia in older adults and is fast becoming
a major societal and economic burden due to an increase in life expectancy. Age seems to …

A ketogenic diet (KD; high-fat, low-carbohydrate) can benefit refractory epilepsy, but
underlying mechanisms are unknown. We used mice inducibly expressing a mutated form of …