Bone morphogenetic proteins
T Katagiri, T Watabe - Cold Spring Harbor Perspectives …, 2016 - cshperspectives.cshlp.org
Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in
extracts derived from bone, are now known to play important roles in a wide array of …
extracts derived from bone, are now known to play important roles in a wide array of …
TGFβ signalling in context
J Massagué - Nature reviews Molecular cell biology, 2012 - nature.com
The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed more
than a decade ago. Since then, the concept of how the TGFβ signal travels from the …
than a decade ago. Since then, the concept of how the TGFβ signal travels from the …
[HTML][HTML] TGF-β and BMP signaling in osteoblast differentiation and bone formation
Transforming growth factor-beta (TGF-β)/bone morphogenic protein (BMP) signaling is
involved in a vast majority of cellular processes and is fundamentally important throughout …
involved in a vast majority of cellular processes and is fundamentally important throughout …
Structural biology and evolution of the TGF-β family
AP Hinck, TD Mueller… - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
We review the evolution and structure of members of the transforming growth factor β (TGF-
β) family, antagonistic or agonistic modulators, and receptors that regulate TGF-β signaling …
β) family, antagonistic or agonistic modulators, and receptors that regulate TGF-β signaling …
Pharmacology of heparin and related drugs
B Mulloy, J Hogwood, E Gray, R Lever, CP Page… - Pharmacological …, 2016 - Elsevier
Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …
decades and is still widely used in clinical practice for a variety of indications. The …
Mechanisms of TGF-β signaling from cell membrane to the nucleus
TGF-β signaling controls a plethora of cellular responses and figures prominently in animal
development. Recent cellular, biochemical, and structural studies have revealed significant …
development. Recent cellular, biochemical, and structural studies have revealed significant …
Bone morphogenetic proteins
DI Chen, M Zhao, GR Mundy - Growth factors, 2004 - Taylor & Francis
Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the
transforming growth factor β (TGFβ) superfamily. The roles of BMPs in embryonic …
transforming growth factor β (TGFβ) superfamily. The roles of BMPs in embryonic …
Bone morphogenetic proteins: a critical review
B Bragdon, O Moseychuk, S Saldanha, D King… - Cellular signalling, 2011 - Elsevier
Bone Morphogenetic Proteins (BMPs) are potent growth factors belonging to the
Transforming Growth Factor Beta superfamily. To date over 20 members have been …
Transforming Growth Factor Beta superfamily. To date over 20 members have been …
[HTML][HTML] Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
DG Winkler, MK Sutherland, JC Geoghegan… - The EMBO …, 2003 - embopress.org
There is an unmet medical need for anabolic treatments to restore lost bone. Human genetic
bone disorders provide insight into bone regulatory processes. Sclerosteosis is a disease …
bone disorders provide insight into bone regulatory processes. Sclerosteosis is a disease …
BMP signalling: agony and antagony in the family
Bone morphogenetic proteins (BMPs) are secreted extracellular matrix (ECM)-associated
proteins that regulate a wide range of developmental processes, including limb and kidney …
proteins that regulate a wide range of developmental processes, including limb and kidney …