Synthetic extracellular matrix (ECM) mimics that can recapitulate the complex biochemical
and mechanical nature of native tissues are needed for advanced models of development …

The gut microbiota has been found to interact with the brain through the microbiota–gut–
brain axis, regulating various physiological processes. In recent years, the impacts of the gut …

There has been growing interest in polymeric systems that break down or undergo property
changes in response to stimuli. Such polymers can play important roles in biological …

Multicellular organisms generate tissues of diverse shapes and functions from cells and
extracellular matrices. Their adhesion molecules mediate cell-cell and cell-matrix …

Organoid models have been used to address important questions in developmental and
cancer biology, tissue repair, advanced modelling of disease and therapies, among other …

Measuring forces within living cells remains a technical challenge. In this Tutorial, we cover
the development of hydrophobic mechanosensing fluorescent probes called Flippers …

The ability of cells to organize into tissues with proper structure and function requires the
effective coordination of proliferation, migration, polarization, and differentiation across …

Morphogenetic events during development shape the body plan and establish structural
foundations for tissue forms and functions. Acquiring spatiotemporal information of …

Advancements in materials-driven mechanobiology have yielded significant progress.
Mechanobiology explores how cellular and tissue mechanics impact development …

Human intestinal organoids (HIOs) derived from pluripotent stem cells or adult stem cell
biopsies represent a powerful platform to study human development, drug testing, and …