Vibrational spectroscopy is an essential tool in chemical analyses, biological assays, and
studies of functional materials. Over the past decade, various coherent nonlinear vibrational …

Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

Infrared (IR; or mid-infrared, MIR; 4000-400 cm− 1; 2500–25,000 nm) spectroscopy has
become one of the most powerful and versatile tools at the disposal of modern bioscience …

Proteins exhibit structural fluctuations over decades of time scales. From the picosecond
side chain motions to aggregates that form over the course of minutes, characterizing protein …

Highlights•We review recent drugs mainly targeting Aβ and how they were identified.•We
report their results from in vitro and in vivo experiments and clinical trials.•We describe …

We report experimental 2D infrared (2D IR) spectra of coherent light–matter excitations––
molecular vibrational polaritons. The application of advanced 2D IR spectroscopy to …

Amyloid formation is implicated in more than 20 human diseases, yet the mechanism by
which fibrils form is not well understood. We use 2D infrared spectroscopy and isotope …

There is an enormous amount of interest in the structures and formation mechanisms of
amyloid fibers. In this Perspective, we review the most common structural motifs of amyloid …

Although it is widely known that trimethylamine N-oxide (TMAO), an osmolyte used by
nature, stabilizes the folded state of proteins, the underlying mechanism of action is not …

The first step toward understanding most of the chemical and biological processes in
condensed phases is to accurately describe solute− solvent interaction energy and to …