Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …

The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system
forms the major node of cellular and organismal defense against oxidative and electrophilic …

Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …

Transcription factor nuclear factor erythroid 2‐related factor 2 (Nrf2) is a major regulator of
antioxidant response element‐(ARE‐) driven cytoprotective protein expression. The …

Nrf2 acts as a sensor of oxidative or electrophilic stress and prevents genome instability. The
activation of Nrf2 signaling induces ARE-dependent expression of detoxifying and …

Multiple sclerosis (MS) is a multifactorial disease of the central nervous system (CNS)
characterized by an inflammatory process and demyelination. The etiology of the disease is …

Covering: up to 2020 The transcription factor NRF2 is one of the body's major defense
mechanisms, driving transcription of> 300 antioxidant response element (ARE)-regulated …

Natural pentacyclic triterpenoids (PTs) have been often reported to exhibit a wide range of
biological activities. Among them, the anticancer and anti-inflammatory activities are the …

Significance: The nuclear factor erythroid 2-related factor 2 (NRF2)-Kelch-like ECH-
associated protein 1 (KEAP1) system is a master regulator of redox homeostasis and cell …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) plays a
critical role in the maintenance of cellular redox and metabolic homeostasis, as well as the …