PET versus SPECT: strengths, limitations and challenges

A Rahmim, H Zaidi - Nuclear medicine communications, 2008 - journals.lww.com
The recent introduction of high-resolution molecular imaging technology is considered by
many experts as a major breakthrough that will potentially lead to a revolutionary paradigm …

Review and current status of SPECT scatter correction

BF Hutton, I Buvat, FJ Beekman - Physics in Medicine & Biology, 2011 - iopscience.iop.org
Detection of scattered gamma quanta degrades image contrast and quantitative accuracy of
single-photon emission computed tomography (SPECT) imaging. This paper reviews …

ICRU REPORT 96, dosimetry-guided radiopharmaceutical therapy

G Sgouros, WE Bolch, A Chiti… - Journal of the …, 2021 - journals.sagepub.com
The International Commission on Radiation Units and Measurements (ICRU), since its
inception in 1925, has had as its principal objective the development of internationally …

MIRD pamphlet no. 23: quantitative SPECT for patient-specific 3-dimensional dosimetry in internal radionuclide therapy

YK Dewaraja, EC Frey, G Sgouros… - Journal of Nuclear …, 2012 - Soc Nuclear Med
In internal radionuclide therapy, a growing interest in voxel-level estimates of tissue-
absorbed dose has been driven by the desire to report radiobiologic quantities that account …

Improved quantitative 90Y bremsstrahlung SPECT/CT reconstruction with Monte Carlo scatter modeling

YK Dewaraja, SY Chun, RN Srinivasa… - Medical …, 2017 - Wiley Online Library
Purpose In 90Y microsphere radioembolization (RE), accurate post‐therapy imaging‐based
dosimetry is important for establishing absorbed dose versus outcome relationships for …

The value of 99mTc-MAA SPECT/CT for lung shunt estimation in 90Y radioembolization: a phantom and patient study

JD Allred, J Niedbala, JK Mikell, D Owen, KA Frey… - EJNMMI research, 2018 - Springer
Background A major toxicity concern in radioembolization therapy of hepatic malignancies is
radiation-induced pneumonitis and sclerosis due to hepatopulmonary shunting of 90 Y …

Quantitative Monte Carlo‐based holmium‐166 SPECT reconstruction

M Elschot, MLJ Smits, JFW Nijsen, MGEH Lam… - Medical …, 2013 - Wiley Online Library
Purpose: Quantitative imaging of the radionuclide distribution is of increasing interest for
microsphere radioembolization (RE) of liver malignancies, to aid treatment planning and …

Impact of reconstruction parameters on quantitative I-131 SPECT

CAJ Van Gils, C Beijst, R Van Rooij… - Physics in Medicine & …, 2016 - iopscience.iop.org
Radioiodine therapy using I-131 is widely used for treatment of thyroid disease or
neuroendocrine tumors. Monitoring treatment by accurate dosimetry requires quantitative …

Correction for collimator-detector response in SPECT using point spread function template

SY Chun, JA Fessler… - IEEE transactions on …, 2012 - ieeexplore.ieee.org
Compensating for the collimator-detector response (CDR) in SPECT is important for
accurate quantification. The CDR consists of both a geometric response and a septal …

Scientific developments in imaging and dosimetry for molecular radiotherapy

M Bardiès, JI Gear - Clinical Oncology, 2021 - Elsevier
Molecular radiotherapy is a rapidly develo** field with new vector and isotope
combinations continually added to market. As with any radiotherapy treatment, it is vital that …