Natural product synthesis has lain at the heart of organic chemistry. Complex structures of
natural products have inspired chemists to develop new methods and strategies. The utility …

Rearranged homoisoflavonoids constitute a unique group of natural products, renowned for
their structural diversity and complexity. These compounds, derived from modifications in the …

The unique reactivity of in situ generated propargylic para-quinone methides as a new type
of five-carbon synthon has been discovered by a novel bismuth (III)-catalyzed tandem …

The Pd-catalyzed reaction between o-iodoallylbenzene and tosylhydrazones gives rise to
indene derivatives through a process that involves a carbene migratory insertion followed by …

Described herein is a concise total synthesis of (+)-brazilin from readily available 4-bromo-1,
2-dimethoxybenzene. In this synthetic route, a Sharpless asymmetric dihydroxylation was …

Palladium-catalyzed carbene insertion was utilized in a formal synthesis of (±)-
picropodophyllone and a total synthesis of (±)-brazilin. All prior syntheses of brazilin have …

The tenacious biofilms formed by Streptococcus mutans are resistant to conventional
antibiotics and current treatments. There is a growing need for novel therapeutics that …

Brazilin, structurally composed of a chroman skeleton cis-fused with a 2, 3-dihydro-1 H-
indene unit, is an important active component of the famous traditional Chinese medicine …

Described herein is a novel one-pot, three-component reaction where aldehydes, electron-
rich arenes, and TMSCN in the presence of BF3-OEt2 allowed direct access to a number of …

A chemical backbone of tetracyclic homoisoflavanoid natural products such as brazilin
inspired us to design a new chemical scaffold, 6a, 11b-dihydroindeno [2, 1-c] chromen-7 …