Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cells

H Chen, M Lombès, D Le Menuet - Molecular brain, 2017 - Springer
Brain-derived neurotrophic factor (BDNF) is involved in many functions such as neuronal
growth, survival, synaptic plasticity and memorization. Altered expression levels are …

Epidermal glucocorticoid and mineralocorticoid receptors act cooperatively to regulate epidermal development and counteract skin inflammation

J Bigas, LM Sevilla, E Carceller, J Boix, P Pérez - Cell death & disease, 2018 - nature.com
Endogenous and synthetic glucocorticoids (GCs) regulate epidermal development and
combat skin inflammatory diseases. GC actions can be mediated through the GC receptor …

The mineralocorticoid receptor plays a crucial role in macrophage development and function

E Faught, MJM Schaaf - Endocrinology, 2023 - academic.oup.com
Stress and the attendant rise in glucocorticoids (GCs) results in a potent suppression of the
immune system. To date, the anti-inflammatory role of GCs, via activation of the …

P38 MAPK and glucocorticoid receptor crosstalk in bronchial epithelial cells

S Lea, J Li, J Plumb, K Gaffey, S Mason… - Journal of Molecular …, 2020 - Springer
Abstract p38 MAPK inhibition may have additive and synergistic anti-inflammatory effects
when used with corticosteroids. We investigated crosstalk between p38 MAPK inhibitors and …

The mineralocorticoid receptor modulates timing and location of genomic binding by glucocorticoid receptor in response to synthetic glucocorticoids in keratinocytes

E Carceller‐Zazo, LM Sevilla… - The FASEB …, 2023 - Wiley Online Library
Glucocorticoids (GCs) exert potent antiproliferative and anti‐inflammatory properties,
explaining their therapeutic efficacy for skin diseases. GCs act by binding to the GC receptor …

Maternal high-fat diet induces sex-specific changes to glucocorticoid and inflammatory signaling in response to corticosterone and lipopolysaccharide challenge in …

S Wijenayake, MF Rahman, CMW Lum… - Journal of …, 2020 - Springer
Background Maternal obesity as a result of high levels of saturated fat (HFD) consumption
leads to significant negative health outcomes in both mother and exposed offspring …

Spironolactone-induced degradation of the TFIIH core complex XPB subunit suppresses NF-κB and AP-1 signalling

JM Elinoff, LY Chen, EJ Dougherty… - Cardiovascular …, 2018 - academic.oup.com
Aims Spironolactone (SPL) improves endothelial dysfunction and survival in heart failure.
Immune modulation, including poorly understood mineralocorticoid receptor (MR) …

[HTML][HTML] Genetic profiling of glucocorticoid (NR3C1) and mineralocorticoid (NR3C2) receptor polymorphisms before starting therapy with androgen receptor inhibitors …

M Morales, P Martín-Vasallo, J Ávila - Biomedicines, 2022 - mdpi.com
Enzalutamide is a nonsteroidal inhibitor of the androgen receptor (AR) signaling pathway
and is used to treat patients with metastatic castration-resistant prostate cancer. However …

Mineralocorticoid receptor antagonist treatment of established pulmonary arterial hypertension improves interventricular dependence in the SU5416-hypoxia rat …

M Lu, LY Chen, S Gairhe, AJ Mazer… - … of Physiology-Lung …, 2022 - journals.physiology.org
Treatment with mineralocorticoid receptor (MR) antagonists beginning at the outset of
disease, or early thereafter, prevents pulmonary vascular remodeling in preclinical models …

Specific Activation of the Alternative Cardiac Promoter of Cacna1c by the Mineralocorticoid Receptor

TR Mesquita, G Auguste, D Falcón… - Circulation …, 2018 - ahajournals.org
Rationale: The MR (mineralocorticoid receptor) antagonists belong to the current therapeutic
armamentarium for the management of cardiovascular diseases, but the mechanisms …