Adrenal tumors are commonly discovered incidentally on cross-sectional abdominal
imaging performed for reasons other than adrenal mass. Incidence of adrenal tumors …

The majority of incidentally discovered adrenal tumours are benign adrenocortical
adenomas and the prevalence of adrenocortical adenomas is around 1–7% on cross …

Patients with primary bilateral macronodular adrenal hyperplasia (PBMAH) usually present
bilateral benign adrenocortical macronodules at imaging and variable levels of cortisol …

Adrenal incidentalomas (AI) may be associated with a mild autonomous cortisol secretion
(MACS) in up to one third of cases. There is growing evidence that MACS patients actually …

Steroidogenesis inhibitors can be given to control the hypercortisolism of Cushing's
syndrome in various situations: when surgery has been unsuccessful or not possible; in …

Endogenous Cushing's syndrome (CS) is a rare endocrine condition frequently caused by a
tumor resulting in elevated cortisol levels. Cushing's disease (CD) caused by an …

The circadian rhythm derives from the integration of many signals that shape the expression
of clock-related genes in a 24-hour cycle. Biological tasks, including cell proliferation …

The daily rhythm of the hypothalamo-pituitary-adrenal (HPA) axis is regulated by the central
clock in the suprachiasmatic nucleus. Cortisol, a glucocorticoid, acts as a secondary …

The 1 st line treatment of Cushing's syndrome is surgery, whatever the aetiology. The role of
pharmacological treatment is clear in cases where surgery fails or is impossible, in cases of …

Primary bilateral macronodular adrenal hyperplasia (PBMAH), characterized by bilateral
benign adrenal macronodules (> 1 cm) potentially responsible for variable levels of cortisol …