Skin tissue wound healing proceeds through four major stages, including hematoma
formation, inflammation, and neo-tissue formation, and culminates with tissue remodeling …

The promise of cancer gene therapeutics is hampered by difficulties in the in vivo delivery to
the targeted tumor cells, and systemic delivery remains to be the biggest challenge to be …

The desired mechanical and biological performances of collagen that have led to its broad
application as a building block in the biomedical field attributed to its intrinsic hierarchical …

Abstract Globally, more than 1.5 million patients undergo bone graft surgeries annually, and
the development of biomaterial scaffolds that mimic natural bone for bone grafting remains a …

Gene therapy involves the introduction of foreign genetic material into cells in order exert a
therapeutic effect. The application of gene therapy to the field of orthopaedic tissue …

Since the discovery of the “starburst polymer”, later renamed as dendrimer, this class of
polymers has gained considerable attention for numerous biomedical applications, due …

MicroRNA (miRNA) directs post-transcriptional regulation of a network of genes by targeting
mRNA. Although relatively recent in development, many miRNAs direct differentiation of …

A hollow mesoporous silica nanoparticle (HMSNP) based drug/siRNA co‐delivery system
was designed and fabricated, aiming at overcoming multidrug resistance (MDR) in cancer …

RNAi can specifically regulate gene expression, but efficient delivery of siRNA in vivo is
difficult while it has been shown that modified carbon nanotubes (CNT) protect siRNA …

RNA interference (RNAi) has just made it through the pipeline to clinical trials. However, in
order for RNAi to serve as an ideal personalized therapeutics and be clinically approved …