Single-cell epigenomics and spatiotemporal transcriptomics reveal human cerebellar development

S Zhong, M Wang, L Huang, Y Chen, Y Ge… - Nature …, 2023 - nature.com
Human cerebellar development is orchestrated by molecular regulatory networks to achieve
cytoarchitecture and coordinate motor and cognitive functions. Here, we combined single …

Human photoreceptor cells from different macular subregions have distinct transcriptional profiles

AP Voigt, NK Mullin, SS Whitmore… - Human molecular …, 2021 - academic.oup.com
The human neural retina is a light sensitive tissue with remarkable spatial and cellular
organization. Compared with the periphery, the central retina contains more densely packed …

Neurochemical atlas of the rabbit spinal cord

A Veshchitskii, P Shkorbatova… - Brain Structure and …, 2024 - Springer
Complex neurophysiological and morphologic experiments require suitable animal models
for investigation. The rabbit is one of the most successful models for studying spinal cord …

An allelic series of spontaneous Rorb mutant mice exhibit a gait phenotype, changes in retina morphology and behavior, and gene expression signatures associated …

GC Murray, JA Bubier, OJ Zinder… - G3: Genes …, 2023 - academic.oup.com
The Retinoid-related orphan receptor beta (RORβ) gene encodes a developmental
transcription factor and has 2 predominant isoforms created through alternative first exon …

Decay of skin-specific gene modules in Pangolins

B Pinto, R Valente, F Caramelo, R Ruivo… - Journal of Molecular …, 2023 - Springer
The mammalian skin exhibits a rich spectrum of evolutionary adaptations. The
pilosebaceous unit, composed of the hair shaft, follicle, and the sebaceous gland, is the …

Comparative analysis of genomic inbreeding parameters and runs of homozygosity islands in several fancy and meat rabbit breeds

M Ballan, G Schiavo, S Bovo, M Schiavitto… - Animal …, 2022 - Wiley Online Library
Runs of homozygosity (ROH) are defined as long stretches of DNA homozygous at each
polymorphic position. The proportion of genome covered by ROH and their length are …

Genomic profile of Parkinson's disease in Asians

V Besin, FM Humardani, T Yulianti, M Justyn - Clinica Chimica Acta, 2024 - Elsevier
Parkinson's Disease (PD) has witnessed an alarming rise in prevalence, highlighting the
suboptimal nature of early diagnostic and therapeutic strategies. To address this issue …

Population genomic structures and signatures of selection define the genetic uniqueness of several fancy and meat rabbit breeds

M Ballan, S Bovo, F Bertolini, G Schiavo… - Journal of Animal …, 2023 - Wiley Online Library
Following the recent domestication process of the European rabbit (Oryctolagus cuniculus),
many different breeds and lines, distinguished primarily by exterior traits such as coat colour …

[LLIBRE][B] Mouse Genetic Approaches to Understand Neurological Phenotypes

GC Murray - 2024 - search.proquest.com
Rare diseases, though individually uncommon, collectively affect approximately 350 million
people worldwide, and there are no effective treatments for most rare diseases. Rare …

An allelic series of spontaneous mutations in Rorb cause a gait phenotype, retinal abnormalities, and transcriptomic changes relevant to human neurodevelopmental …

GC Murray, J Bubier, OJ Zinder, B Harris, J Clark… - bioRxiv, 2021 - biorxiv.org
ABSTRACT Rorb encodes the Retinoic Acid Receptor-related orphan receptor beta.
Mutations in either of the two transcripts of Rorb cause defects in multiple systems, including …