An overview of the synthesis and antimicrobial, antiprotozoal, and antitumor activity of thiazole and bisthiazole derivatives
Thiazole, a five-membered heteroaromatic ring, is an important scaffold of a large number of
synthetic compounds. Its diverse pharmacological activity is reflected in many clinically …
synthetic compounds. Its diverse pharmacological activity is reflected in many clinically …
[HTML][HTML] Novel Small Molecule-Based Acetylcholinesterase (AChE) Inhibitors: from Biological Perspective to Recent Developments
A Sobha, A Ganapathy, S Mohan… - European Journal of …, 2024 - Elsevier
Alzheimer's disease (AD) is a chronic neurodegenerative disorder that imposes a
substantial socioeconomic burden globally. The increasing prevalence of AD, coupled with …
substantial socioeconomic burden globally. The increasing prevalence of AD, coupled with …
Design, synthesis, biological evaluation, and docking study of novel dual-acting thiazole-pyridiniums inhibiting acetylcholinesterase and β-amyloid aggregation for …
New compounds containing thiazole and pyridinium moieties were designed and
synthesized. The potency of the synthesized compounds as selective inhibitors of …
synthesized. The potency of the synthesized compounds as selective inhibitors of …
Piperazine-substituted chalcones: A new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders
Abstract Eleven piperazine-containing 1, 3-diphenylprop-2-en-1-one derivatives (PC1-
PC11) were evaluated for their inhibitory activities against monoamine oxidases (MAOs) …
PC11) were evaluated for their inhibitory activities against monoamine oxidases (MAOs) …
Discovery of novel benzofuran-based derivatives as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease: Design, synthesis, biological evaluation …
SS Abd El-Karim, MM Anwar, NS Ahmed… - European Journal of …, 2023 - Elsevier
A series of novel benzofuran-based compounds 7a-s were designed, synthesized, and
investigated in vitro as acetylcholinesterase inhibitors (AChEIs). Compounds 7c and 7e …
investigated in vitro as acetylcholinesterase inhibitors (AChEIs). Compounds 7c and 7e …
Sulfur-containing therapeutics in the treatment of Alzheimer's disease
Sulfur is widely existent in natural products and synthetic organic compounds as
organosulfur, which are often associated with a multitude of biological activities …
organosulfur, which are often associated with a multitude of biological activities …
The synthesis, photophysical properties, DFT study and textile applications of fluorescent azo dyes bearing coumarin-thiazole
In this study, four novel coumarin-thiazole-based azo dyes were prepared by coupling N-
methyl-N-phenylaniline and 3-methyl-1-phenyl-2-pyrazoline-5-one with coumarin-2 …
methyl-N-phenylaniline and 3-methyl-1-phenyl-2-pyrazoline-5-one with coumarin-2 …
Synthesis and AChE inhibitory activity of novel thiazolylhydrazone derivatives
Alzheimer's disease (AD) is the most common of the degenerative brain diseases and is
described together with the impairment of cognitive function. Patients with AD lose the …
described together with the impairment of cognitive function. Patients with AD lose the …
Synthesis and molecular docking simulation of new benzimidazole–thiazole hybrids as cholinesterase inhibitors
DH Dawood, AM Srour, MA Omar… - Archiv der …, 2024 - Wiley Online Library
Dementia is a cognitive disturbance that is generally correlated with central nervous system
diseases, especially Alzheimer's disease. The limited number of medications available is …
diseases, especially Alzheimer's disease. The limited number of medications available is …
The antiviral drug tilorone is a potent and selective inhibitor of acetylcholinesterase
Acetylcholinesterase (AChE) is an important drug target in neurological disorders like
Alzheimer's disease, Lewy body dementia, and Parkinson's disease dementia as well as for …
Alzheimer's disease, Lewy body dementia, and Parkinson's disease dementia as well as for …