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Perspective on the current state of the LRRK2 field
Almost 2 decades after linking LRRK2 to Parkinson's disease, a vibrant research field has
developed around the study of this gene and its protein product. Recent studies have begun …
developed around the study of this gene and its protein product. Recent studies have begun …
Small-molecule LRRK2 inhibitors for PD therapy: current achievements and future perspectives
J Hu, D Zhang, K Tian, C Ren, H Li, C Lin… - European Journal of …, 2023 - Elsevier
Leucine-rich repeat kinase 2 (LRRK2) is a multifunctional protein that orchestrates a diverse
array of cellular processes, including vesicle transport, autophagy, lysosome degradation …
array of cellular processes, including vesicle transport, autophagy, lysosome degradation …
[HTML][HTML] Mechanisms of glucocerebrosidase dysfunction in Parkinson's disease
Beta-glucocerebrosidase is a lysosomal hydrolase, encoded by GBA1 that represents the
most common risk gene associated with Parkinson's disease (PD) and Lewy Body …
most common risk gene associated with Parkinson's disease (PD) and Lewy Body …
The R1441C-Lrrk2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner in mice
Age is the greatest risk factor for many neurodegenerative diseases, yet immune system
aging, a contributor to neurodegeneration, is understudied. Genetic variation in the LRRK2 …
aging, a contributor to neurodegeneration, is understudied. Genetic variation in the LRRK2 …
Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson's disease
Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are progressive
neurodegenerative diseases characterized by the accumulation of misfolded α-synuclein in …
neurodegenerative diseases characterized by the accumulation of misfolded α-synuclein in …
A potential patient stratification biomarker for Parkinson´ s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells
Parkinson´ s disease (PD) is a common neurodegenerative movement disorder and leucine-
rich repeat kinase 2 (LRRK2) is a promising therapeutic target for disease intervention …
rich repeat kinase 2 (LRRK2) is a promising therapeutic target for disease intervention …
ASO-mediated knockdown or kinase inhibition of G2019S-Lrrk2 modulates lysosomal tubule-associated antigen presentation in macrophages
Genetic variation around the LRRK2 gene affects risk for both familial and sporadic
Parkinson's disease (PD). LRRK2 levels have become an appealing target for potential PD …
Parkinson's disease (PD). LRRK2 levels have become an appealing target for potential PD …
The interplay between monocytes, α-synuclein and LRRK2 in Parkinson's disease
The accumulation of aggregated α-synuclein in susceptible neurons in the brain, together
with robust activation of nearby myeloid cells, are pathological hallmarks of Parkinson's …
with robust activation of nearby myeloid cells, are pathological hallmarks of Parkinson's …
Live cell in situ lysosomal GCase activity correlates to alpha-synuclein levels in human differentiated neurons with LRRK2 and GBA1 mutations
A Labrador-Garrido, S Zhong, L Hughes… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction Heterozygous mutations in GBA1, which encodes the lysosomal hydrolase
glucocerebrosidase (GCase), are a common risk factor for the neurodegenerative movement …
glucocerebrosidase (GCase), are a common risk factor for the neurodegenerative movement …
GBA1 and The Immune System: A Potential Role in Parkinson's Disease?
It is clear that the immune system and inflammation have a role in Parkinson's disease (PD),
including sporadic PD and some genetic forms such as LRRK2-associated PD. One of the …
including sporadic PD and some genetic forms such as LRRK2-associated PD. One of the …