Advanced strategies for overcoming endosomal/lysosomal barrier in nanodrug delivery

C Qiu, F **a, J Zhang, Q Shi, Y Meng, C Wang, H Pang… - Research, 2023 - spj.science.org
Nanocarriers have therapeutic potential to facilitate drug delivery, including biological
agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by …

Protein cages: from fundamentals to advanced applications

TGW Edwardson, MD Levasseur, S Tetter… - Chemical …, 2022 - ACS Publications
Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

Computational modeling of realistic cell membranes

SJ Marrink, V Corradi, PCT Souza, HI Ingolfsson… - Chemical …, 2019 - ACS Publications
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …

Recent advances in cell penetrating peptide-based anticancer therapies

J Habault, JL Poyet - Molecules, 2019 - mdpi.com
Cell-penetrating-peptides (CPPs) are small amino-acid sequences characterized by their
ability to cross cellular membranes. They can transport various bioactive cargos inside cells …

Predicting cell-penetrating peptides using machine learning algorithms and navigating in their chemical space

ECL de Oliveira, K Santana, L Josino… - Scientific reports, 2021 - nature.com
Cell-penetrating peptides (CPPs) are naturally able to cross the lipid bilayer membrane that
protects cells. These peptides share common structural and physicochemical properties and …

Cell penetrating peptides: A versatile vector for co-delivery of drug and genes in cancer

MM Khan, N Filipczak, VP Torchilin - Journal of Controlled Release, 2021 - Elsevier
Biological barriers hamper the efficient delivery of drugs and genes to targeted sites. Cell
penetrating peptides (CPP) have the ability to rapidly internalize across biological …

Delivery systems for nucleic acids and proteins: Barriers, cell capture pathways and nanocarriers

JD Torres-Vanegas, JC Cruz, LH Reyes - Pharmaceutics, 2021 - mdpi.com
Gene therapy has been used as a potential approach to address the diagnosis and
treatment of genetic diseases and inherited disorders. In this line, non-viral systems have …

Synthesis of lipid membranes for artificial cells

KA Podolsky, NK Devaraj - Nature Reviews Chemistry, 2021 - nature.com
A major goal of synthetic biology is to understand the transition between non-living matter
and life. The bottom-up development of an artificial cell would provide a minimal system with …

Challenge to overcome current limitations of cell-penetrating peptides

GC Kim, DH Cheon, Y Lee - Biochimica et Biophysica Acta (BBA)-Proteins …, 2021 - Elsevier
The penetration of biological membranes is a prime obstacle for the delivery of
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …

It's getting complicated—a fresh look at p53-MDM2-ARF triangle in tumorigenesis and cancer therapy

CP Kung, JD Weber - Frontiers in cell and developmental biology, 2022 - frontiersin.org
Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic
stresses, are our bodies' greatest weapons to battle against cancer onset and development …