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Advanced strategies for overcoming endosomal/lysosomal barrier in nanodrug delivery
C Qiu, F **a, J Zhang, Q Shi, Y Meng, C Wang, H Pang… - Research, 2023 - spj.science.org
Nanocarriers have therapeutic potential to facilitate drug delivery, including biological
agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by …
agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by …
Protein cages: from fundamentals to advanced applications
Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …
Computational modeling of realistic cell membranes
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
Recent advances in cell penetrating peptide-based anticancer therapies
J Habault, JL Poyet - Molecules, 2019 - mdpi.com
Cell-penetrating-peptides (CPPs) are small amino-acid sequences characterized by their
ability to cross cellular membranes. They can transport various bioactive cargos inside cells …
ability to cross cellular membranes. They can transport various bioactive cargos inside cells …
Predicting cell-penetrating peptides using machine learning algorithms and navigating in their chemical space
Cell-penetrating peptides (CPPs) are naturally able to cross the lipid bilayer membrane that
protects cells. These peptides share common structural and physicochemical properties and …
protects cells. These peptides share common structural and physicochemical properties and …
Cell penetrating peptides: A versatile vector for co-delivery of drug and genes in cancer
Biological barriers hamper the efficient delivery of drugs and genes to targeted sites. Cell
penetrating peptides (CPP) have the ability to rapidly internalize across biological …
penetrating peptides (CPP) have the ability to rapidly internalize across biological …
Delivery systems for nucleic acids and proteins: Barriers, cell capture pathways and nanocarriers
Gene therapy has been used as a potential approach to address the diagnosis and
treatment of genetic diseases and inherited disorders. In this line, non-viral systems have …
treatment of genetic diseases and inherited disorders. In this line, non-viral systems have …
Synthesis of lipid membranes for artificial cells
A major goal of synthetic biology is to understand the transition between non-living matter
and life. The bottom-up development of an artificial cell would provide a minimal system with …
and life. The bottom-up development of an artificial cell would provide a minimal system with …
Challenge to overcome current limitations of cell-penetrating peptides
The penetration of biological membranes is a prime obstacle for the delivery of
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …
pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver …
It's getting complicated—a fresh look at p53-MDM2-ARF triangle in tumorigenesis and cancer therapy
Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic
stresses, are our bodies' greatest weapons to battle against cancer onset and development …
stresses, are our bodies' greatest weapons to battle against cancer onset and development …