Despite develo** prenatally, the adipose tissue is unique in its ability to undergo drastic
growth even after reaching its mature size. This development and subsequent maintenance …

Cell migration plays an essential role in cancer metastasis. In cancer invasion through
confined spaces, cells must undergo extensive deformation, which is a capability related to …

We provide an innovative, bioengineering, mechanobiology-based approach to rapidly (2-h)
establish the in vivo metastatic likelihood of patient tumor-samples, where results are in …

Metastases are the leading cause of cancer‐associated deaths. A key process in metastasis
is cell invasiveness, which is driven and controlled by cancer cell interactions with their …

We show that cell-applied, normal mechanical stresses are required for cells to penetrate
into soft substrates, matching experimental observations in invasive cancer cells, while in …

Solid-tumor cell invasion typically occurs by collective migration of attached cell-cohorts, yet
we show here that indirect cell-interactions through the substrate can also drive …

Paclitaxel (Taxol) is a chemotherapy drug widely used to treat different types of solid tumors
(eg ovarian, breast, and pancreatic). Taxol acts by hyper-stabilizing microtubules, inhibiting …

Adipogenesis is a developmental process in which an elongated preadipocyte differentiates
to a round adipocyte along with the accumulation of lipid droplets. In the present study, we …

Non-contacting, adjacent cancer cells can mechanically interact through their substrate to
increase their invasive and migratory capacities that underly metastases-formation. Such …

This chapter presents an overview of the process of cancer metastasis from a
mechanobiological perspective and provides a summary of current cytomechanobiology …