Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Vitamin A or retinol is arguably the most multifunctional vitamin in the human body, as it is
essential from embryogenesis to adulthood. The pleiotropic effects of vitamin A are exerted …

Retinoic acid (RA), the active derivative of vitamin A, a fat-soluble vitamin, plays key roles in
cell growth and differentiation by activating nuclear receptors, RARs (α, β and γ), which are …

In mouse embryonic cells, ligand-activated retinoic acid receptors (RARs) play a key role in
inhibiting pluripotency-maintaining genes and activating some major actors of cell …

The vitamin A derivative, retinoic acid (RA), is essential for embryonic development through
the activation of cognate nuclear receptors, RARs, which work as ligand dependent …

The nuclear retinoic acid receptors interact with specific retinoic acid (RA) response
elements (RAREs) located in the promoters of target genes to orchestrate transcriptional …

The pandemics of obesity and type 2 diabetes have become a concern of public health.
Nutrition plays a key role in these concerns. Insulin as an anabolic hormonal was …

Vitamin A or retinol is a multifunctional vitamin that is essential at all stages of life from
embryogenesis to adulthood. Up to now, it has been accepted that the effects of vitamin A …

The nuclear receptor LRH-1 (Liver Receptor Homolog-1, NR5A2) is a transcription factor
that regulates gene expression programs critical for many aspects of metabolism and …

Retinoic acid (RA) is a vitamin A-derived morphogen controlling important developmental
processes in vertebrates, and more generally in chordates, including axial patterning and …