Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. Countless CRC patients undergo disease progression. As …

Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of
cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85 …

High expression of PD-L1 in tumor cells contributes to tumor immune evasion. However,
whether PD-L1 expression in tumor cells is regulated by the availability of nutrients is …

Extracellular vesicles play crucial roles in intercellular communication in the tumor
microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the …

Cancer cells reprogram their metabolism to become" glycolysis-dominant," which enables
them to meet their energy and macromolecule needs and enhancing their rate of survival …

For decades, great strides have been made in the field of immunometabolism. A plethora of
evidence ranging from basic mechanisms to clinical transformation has gradually embarked …

Osteoarthritis (OA) is an age-related chronic degenerative joint disease where the main
characteristics include progressive degeneration of cartilage, varying degrees of synovitis …

Glucose metabolism is indispensable for cell growth and survival. Hexokinases play pivotal
roles in glucose metabolism through canonical functions of hexokinases as well as in …

Abstract Background & aims N6-methyladenosine (m6A) modification plays a critical role in
progression of hepatocellular carcinoma (HCC), and aerobic glycolysis is a hallmark of …

Cancer heterogeneity remains a significant challenge for effective cancer treatments. Altered
energetics is one of the hallmarks of cancer and influences tumor growth and drug …