Significance: A common link between all forms of acute and chronic kidney injuries,
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …

The incidence of acute kidney injury (AKI) in the intensive care unit (ICU) has increased
during the past decade due to increased acuity as well as increased recognition. Early …

Purpose Current reports on acute kidney injury (AKI) in the intensive care unit (ICU) show
wide variation in occurrence rate and are limited by study biases such as use of incomplete …

The population epidemiology of AKI is not well described. Here, we analyzed data from the
Nationwide Inpatient Sample, a nationally representative dataset, to identify cases of dialysis …

Sepsis is considered a major public health problem. Despite mortality being associated
consistently with organ compromise, the mechanisms by which sepsis causes multiple …

An understanding of the pathologic mechanisms of sepsis-induced AKI emphasizes the
important role of maladaptive responses to the septic insult. Preventive and therapeutic …

Background Studies suggest an association between acute kidney injury (AKI) and long-
term risk for chronic kidney disease (CKD), even following apparent renal recovery. Whether …

Objective: To determine the relationship between long-term mortality and acute kidney injury
(AKI) during hospitalization after major surgery. Summary Background Data: AKI is …

Ten years after Fire and Melo's Nobel Prize for discovery of gene silencing by double-
stranded RNA, a remarkable progress was achieved in RNA interference (RNAi). Changes …

Acute kidney injury is the abrupt reduction in kidney function as determined by elevated
serum creatinine level, a reduction in urine output, or the need for renal replacement …