Bone has a complex hierarchical structure with structural integration from nm to cm. The
understanding of bone structure is develo** rapidly due to improvements in available …

Poly (lactic-co-glycolic acid)(PLGA) is a widely used biodegradable and biocompatible
copolymer in drug delivery systems (DDSs). In this article, we highlight the critical …

Artificial construction of tissue engineering implants with bone-mimicking structure and
osteogenic function is of great significance for bone regeneration, but it remains a …

The evolution of meta-biomaterials has opened up exciting new opportunities for mass
personalisation of biomedical devices. This research paper details the development of a …

Recovery of the collagen structure following Achilles tendon rupture is poor, resulting in a
high risk for re-ruptures. The loading environment during healing affects the mechanical …

Bone morphogenetic protein-2 (BMP-2) has been commercially approved by the Food and
Drug Administration for use in bone defects and diseases. BMP-2 promotes osteogenic …

Critical-size skull defects caused by trauma, infection, and tumor resection raise great
demands for efficient bone substitutes. Herein, a hybrid cross-linked hierarchical …

In certain situations, bones do not heal completely after fracturing. One of these situations is
a critical-size bone defect where the bone cannot heal spontaneously. In such a case …

Background: Factor-free biomaterial scaffolds play an increasingly important role in
promoting in situ bone reconstruction and regeneration. However, the complicated and …

Bone defects are a prevalent issue in orthopedics clinics, and tissue engineering offers a
new hope for treatment. Angiogenesis ability is indispensable during the healing process of …