Stem cells can reside in a state of reversible growth arrest, or quiescence, for prolonged
periods of time. Although quiescence has long been viewed as a dormant, low-activity state …

Understanding adipogenesis, the process of adipocyte development, may provide new ways
to treat obesity and related metabolic diseases. Adipogenesis is controlled by coordinated …

Study of monogenic mitochondrial cardiomyopathies may yield insights into mitochondrial
roles in cardiac development and disease. Here, we combined patient-derived and …

Ribosome profiling has emerged as a technique for measuring translation comprehensively
and quantitatively by deep sequencing of ribosome-protected mRNA fragments. By …

Preclinical and clinical studies implicate endocannabinoids (eCBs) in fear extinction, but the
underlying neural circuit basis of these actions is unclear. Here, we employed in vivo …

Cellular diversity and architectural complexity create barriers to understanding the function
of the mammalian CNS at a molecular level. To address this problem, we have recently …

Astrocytes are specialized and the most abundant cell type in the central nervous system
(CNS). They play important roles in the physiology of the brain. Astrocytes are also critically …

Recent advances have substantially increased the number of genes that are statistically
associated with complex genetic disorders of the CNS such as autism and schizophrenia. It …

Obesity is a major risk factor for adverse outcomes in breast cancer; however, the underlying
molecular mechanisms have not been elucidated. To investigate the role of crosstalk …

Designer nucleases such as TALENS and Cas9 have opened new opportunities to
scarlessly edit the mammalian genome. Here we explored several parameters that influence …