Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Antiplatelet agents and anticoagulants are a mainstay for the prevention and treatment of
thrombosis. However, despite advances in antithrombotic therapy, a fundamental challenge …

Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit
bioinformation bidirectionally across the plasma membrane. Integrin αIIbβ3 is expressed at a …

Abstract The Yorkie homologues YAP (Yes-associated protein) and TAZ (transcriptional
coactivator with PDZ-binding motif, also known as WWTR1), effectors of the Hippo pathway …

Background: PCSK9 (proprotein convertase subtilisin/kexin 9), mainly secreted by the liver
and released into the blood, elevates plasma low-density lipoprotein cholesterol by …

Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall
and soluble agonists, which initiate platelet activation, leading to formation of hemostatic …

Antiplatelet drugs, such as aspirin, P2Y12 antagonists, and glycoprotein (GP) IIb/IIIa
inhibitors, have proved to be successful in reducing the morbidity and mortality associated …

Integrin αIIbβ3 is a highly abundant heterodimeric platelet receptor that can transmit
information bidirectionally across the plasma membrane, and plays a critical role in …

Abstract Human MutT Homolog 1 (MTH1) is a nucleotide pool sanitization enzyme that
hydrolyzes oxidized nucleotides to prevent their mis-incorporation into DNA under oxidative …

Integrins are membrane receptors that mediate cell adhesion and mechanosensing. The
structure–function relationship of integrins remains incompletely understood, despite the …