Molecular mechanisms and cellular functions of cGAS–STING signalling
The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …
GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon genes …
Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway
J Kim, HS Kim, JH Chung - Experimental & Molecular Medicine, 2023 - nature.com
In addition to constituting the genetic material of an organism, DNA is a tracer for the
recognition of foreign pathogens and a trigger of the innate immune system. cGAS functions …
recognition of foreign pathogens and a trigger of the innate immune system. cGAS functions …
Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy
CD8+ T cell-mediated cancer clearance is often suppressed by the interaction between
inhibitory molecules like PD-1 and PD-L1, an interaction acts like brakes to prevent T cell …
inhibitory molecules like PD-1 and PD-L1, an interaction acts like brakes to prevent T cell …
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections
The induction of type I interferons through the transcription factor interferon regulatory factor
3 (IRF3) is considered a major outcome of stimulator of interferon genes (STING) activation …
3 (IRF3) is considered a major outcome of stimulator of interferon genes (STING) activation …
Structures and mechanisms in the cGAS-STING innate immunity pathway
Besides its role as the blueprint of life, DNA can also alert the cell to the presence of
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …
microbial pathogens as well as damaged or malignant cells. A major sensor of DNA that …
NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking
L Zhang, X Wei, Z Wang, P Liu, Y Hou, Y Xu, H Su… - Cell Reports, 2023 - cell.com
It is widely known that stimulator of interferon genes (STING) can trigger nuclear factor κB
(NF-κB) signaling. However, whether and how the NF-κB pathway affects STING signaling …
(NF-κB) signaling. However, whether and how the NF-κB pathway affects STING signaling …
DNA sensing by the cGAS–STING pathway in health and disease
The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …
The balance of STING signaling orchestrates immunity in cancer
KRB Lanng, EL Lauridsen, MR Jakobsen - Nature Immunology, 2024 - nature.com
Over the past decade, it has become clear that the stimulator of interferon genes (STING)
pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored …
pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored …
Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy
Z Zhang, H Zhou, X Ouyang, Y Dong… - Signal transduction and …, 2022 - nature.com
Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …
Activation of STING by targeting a pocket in the transmembrane domain
Stimulator of interferon genes (STING) is an adaptor protein in innate immunity against DNA
viruses or bacteria,,,–. STING-mediated immunity could be exploited in the development of …
viruses or bacteria,,,–. STING-mediated immunity could be exploited in the development of …