Transient receptor potential (TRP) channels are a widely expressed family of 28
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …

Transient receptor potential cation channels subfamily V member 4 (TRPV4) are non-
selective cation channels expressed in different cell types of the central nervous system …

In the past, water homeostasis of the brain was understood as a certain quantitative
equilibrium of water content between intravascular, interstitial, and intracellular spaces …

Introduction Astrocytic Aquaporin 4 (AQP4) and Transient receptor potential vanilloid 4
(TRPV4) channels form a functional complex that likely influences cell volume regulation …

The physiological and neurological correlates of plummeting brain osmolality during edema,
traumatic CNS injury, and severe ischemia are compounded by neuroinflammation. Using …

Traumatic brain injury (TBI) is one of the most common pathological conditions impacting the
central nervous system (CNS). A neurological deficit associated with TBI results from a …

Multiple subfields of neuroscience research are beginning to incorporate astrocytes into
current frameworks of understanding overall brain physiology, neuronal circuitry, and …

Stroke is a life-threatening condition in which accurate diagnoses and timely treatment are
critical for successful neurological recovery. The current acute treatment strategies …

The discovery of the glial-lymphatic or glymphatic fluid clearance pathway in the rodent
brain led researchers to search for a parallel system in humans and to question the …

Transient receptor potential vanilloid 4 (TRPV4) is a nonselective Ca 2+-permeable cation
channel that is a member of the TRP channel family. It is clear that TRPV4 channels are …