[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities

ED Mock, B Gagestein, M van der Stelt - Progress in Lipid Research, 2023 - Elsevier
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

Phosphatidylserine in the brain: metabolism and function

HY Kim, BX Huang, AA Spector - Progress in lipid research, 2014 - Elsevier
Phosphatidylserine (PS) is the major anionic phospholipid class particularly enriched in the
inner leaflet of the plasma membrane in neural tissues. PS is synthesized from …

Inflammation and the two-hit hypothesis of schizophrenia

KA Feigenson, AW Kusnecov, SM Silverstein - … & Biobehavioral Reviews, 2014 - Elsevier
The high societal and individual cost of schizophrenia necessitates finding better, more
effective treatment, diagnosis, and prevention strategies. One of the obstacles in this …

Cognitive enhancement by omega-3 fatty acids from child-hood to old age: findings from animal and clinical studies

DW Luchtman, C Song - Neuropharmacology, 2013 - Elsevier
Omega-(n)-3 polyunsaturated fatty acids (PUFAs), including docosahexaenoic acid (DHA)
and eicosapentaenoic acid (EPA) are major components of neuronal membranes and have …

Perinatal dietary polyunsaturated fatty acids in brain development, role in neurodevelopmental disorders

M Martinat, M Rossitto, M Di Miceli, S Layé - Nutrients, 2021 - mdpi.com
n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential fatty acids that are provided
by dietary intake. Growing evidence suggests that n-3 and n-6 PUFAs are paramount for …

Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism

AA Spector, HY Kim - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2015 - Elsevier
Polyunsaturated fatty acids (PUFA) are oxidized by cytochrome P450 epoxygenases to
PUFA epoxides which function as potent lipid mediators. The major metabolic pathways of …

[HTML][HTML] Brain docosahexaenoic acid uptake and metabolism

RJS Lacombe, R Chouinard-Watkins… - Molecular Aspects of …, 2018 - Elsevier
Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the
brain where it serves to regulate several important processes and, in addition, serves as a …

Discovery of essential fatty acids

AA Spector, HY Kim - Journal of lipid research, 2015 - ASBMB
Dietary fat was recognized as a good source of energy and fat-soluble vitamins by the first
part of the 20th century, but fatty acids were not considered to be essential nutrients because …

Emerging class of omega-3 fatty acid endocannabinoids & their derivatives

JE Watson, JS Kim, A Das - Prostaglandins & other lipid mediators, 2019 - Elsevier
Cannabinoid receptor activation is involved in homeostatic regulation of the body. These
receptors are activated by cannabinoids, that include the active constituents of Cannabis …

Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function

JW Lee, BX Huang, HS Kwon, MA Rashid… - Nature …, 2016 - nature.com
Abstract Docosahexaenoic acid (DHA, 22: 6n-3) is an omega-3 fatty acid essential for proper
brain development. N-docosahexaenoylethanolamine (synaptamide), an endogenous …