Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell
adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby …

Integrins are cell adhesion molecules that mediate cell-cell, cell–extracellular matrix, and
cell-pathogen interactions. They play critical roles for the immune system in leukocyte …

Regulation of integrin affinity (activation) is essential for metazoan development and for
many pathological processes. Binding of the talin phosphotyrosine-binding (PTB) domain to …

Regulation of cell-cell and cell-matrix interaction is essential for the normal physiology of
metazoans and is important in many diseases. Integrin adhesion receptors can rapidly …

Abstract αβ heterodimeric integrins mediate dynamic adhesive cell-cell and cell-extracellular
matrix (ECM) interactions in metazoa that are critical in growth and development …

The platelet integrin αIIbβ3 is required for platelet aggregation. Like other integrins, αIIbβ3
resides on cell surfaces in an equilibrium between inactive and active conformations …

Integrin signaling is bidirectional.'Inside-out'signals regulate integrin affinity for adhesive
ligands, and ligand-dependent 'outside-in'signals regulate cellular responses to adhesion …

Cells recognize and respond to their extracellular environment through transmembrane
receptors such as integrins, which physically connect the extracellular matrix to the …

Background Integrin receptors, composed of transmembrane α and β subunits, are essential
for the development and functioning of multicellular animals. Agonist stimulation leads cells …

Heterodimeric integrin adhesion receptors regulate cell migration, survival and
differentiation in metazoa by communicating signals bi‐directionally across the plasma …