p62 is a highly conserved, multi-domain, and multi-functional adaptor protein critically
involved in several important cellular processes. Via its pronounced domain architecture …

The fate of a cell is determined by multiple signaling pathways in response to a range of
stimuli. Probably the most prominent cell death mechanism is apoptosis which can be …

Interferon-inducible guanylate-binding proteins (GBPs) promote cell-intrinsic defense
through host cell death. GBPs target pathogens and pathogen-containing vacuoles and …

p62/SQSTM1 is a multiprotein interaction hub forming cellular punctate structures known as
p62 bodies. p62 is centrally involved in the degradation of ubiquitinated cargo through …

Autophagy is an essential function to breakdown cellular proteins and organelles to recycle
for new nutrient building blocks. In colorectal cancer, the importance of autophagy is …

p62 is a versatile protein involved in the delicate balance between cell death and survival,
which is fundamental for cell fate decision in the context of both cancer and …

The cytokine interleukin-1β (IL-1β) has pivotal roles in antimicrobial immunity, but also
incites inflammatory disease. Bioactive IL-1β is released following proteolytic maturation of …

Nutrients not only act as building blocks but also as signaling molecules. Nutrient-availability
promotes cell growth and proliferation and suppresses catabolic processes, such as …

Amyloids are fibrous proteins aggregated into toxic forms that are implicated in several
chronic disorders. More than 30 diseases show deposition of fibrous amyloid proteins …

Mammalian target of rapamycin (mTOR) is a central regulator of mammalian metabolism
and physiology. Aberrant hyperactivation of the mTOR pathway promotes tumor growth and …