Since the introduction of penicillin, β-lactam antibiotics have been the antimicrobial agents
of choice. Unfortunately, the efficacy of these life-saving antibiotics is significantly threatened …

Carbapenems are considered as last-resort antibiotics for the treatment of infections caused
by multidrug-resistant Gram-negative bacteria. With the increasing use of carbapenems in …

Escherichia coli sequence type 131 (ST131) and Klebsiella pneumoniae ST258 emerged in
the 2000s as important human pathogens, have spread extensively throughout the world …

The spread of Enterobacteriaceae, primarily Klebsiella pneumoniae, producing KPC, VIM,
IMP, and NDM carbapenemases, is causing an unprecedented public health crisis …

Carbapenem resistance, mainly among Gram-negative pathogens, is an ongoing public-
health problem of global dimensions. This type of antimicrobial resistance, especially when …

Multilocus sequence ty** reveals that many bacterial species have a clonal structure and
that some clones are widespread. This underlying phylogeny was not revealed by pulsed …

First variants of the Klebsiella pneumoniae carbapenemase (KPC), KPC-2 and KPC-3, have
encountered a worldwide success, particularly in K. pneumoniae isolates. These beta …

Abstract Objectives Infections caused by Klebsiella pneumoniae (Kp) carbapenemase
(KPC)-producing strains of Kp have become a significant threat in recent years. To assess …

Bacteria producing Klebsiella pneumoniae carbapenemases (KPCs) are rapidly emerging
as a cause of multidrug-resistant infections worldwide. Bacterial isolates harbouring these …

Carbapenems, once considered the last line of defense against of serious infections with
Enterobacteriaceae, are threatened with extinction. The increasing isolation of carbapenem …