Corneal wound healing is a complex process involving cell death, migration, proliferation,
differentiation, and extracellular matrix remodeling. Many similarities are observed in the …

Aniridia, a rare congenital disease, is often characterized by a progressive, pronounced
limbal insufficiency and ocular surface pathology termed aniridia-associated keratopathy …

The accessibility and transparency of the cornea permit robust stem cell labeling and in vivo
cell fate map**. Limbal epithelial stem cells (LSCs) that renew the cornea are traditionally …

Epithelial cell monolayers show remarkable displacement and velocity correlations over
distances of ten or more cell sizes that are reminiscent of supercooled liquids and active …

Purpose: Single-cell RNA-sequencing (scRNA-seq) was used to interrogate the relatively
rare stem (SC) and early transit amplifying (TA) cell populations in limbal/corneal epithelia …

Brainbow is a genetic cell-labeling technique where hundreds of different hues can be
generated by stochastic and combinatorial expression of a few spectrally distinct fluorescent …

The cornea is our window to the world and our vision is critically dependent on corneal
clarity and integrity. Its epithelium represents one of the most rapidly regenerating …

The factors that regulate the size of organs to ensure that they fit within an organism are not
well understood. A simple organ, the ocular lens serves as a useful model with which to …

To identify the cells at the origin of melanoma, we combined single-cell lineage-tracing and
transcriptomics approaches with time-lapse imaging. A mouse model that recapitulates key …

A strong cohort of evidence exists that supports the localisation of corneal stem cells at the
limbus. The distinguishing characteristics of limbal cells as stem cells include slow cycling …