Our understanding of the molecular properties of kainate receptors and their involvement in
synaptic physiology has progressed significantly over the last 30 years. A plethora of studies …

Glutamate receptors (GluRs) mediate most of the excitatory neurotransmission in the
mammalian central nervous system (CNS). In addition, they are involved in plastic changes …

Glutamic acid is the principal excitatory neurotransmitter in the mammalian central nervous
system. Glutamic acid binds to a variety of excitatory amino acid receptors, which are ligand …

Crystal structures of the GluR2 ligand binding core (S1S2) have been determined in the apo
state and in the presence of the antagonist DNQX, the partial agonist kainate, and the full …

Since 1975, Robert Julien's A Primer of Drug Action has been the definitive guide to the
effects of psychoactive drugs on the brain and on behavior. Now fully updated, this popular …

Movement, the fundamental component of behavior and the principal extrinsic action of the
brain, is produced when skeletal muscles contract and relax in response to patterns of action …

Glutamate, the neurotransmitter at most excitatory synapses in the brain, activates a variety
of receptor subtypes that can broadly be divided into ionotropic (ligand-gated ion channels) …

Abstract l-glutamate, the neurotransmitter of the majority of excitatory synapses in the brain,
acts on three classes of ionotropic receptors: NMDA (N-methyl-d-aspartate), AMPA (α-amino …

(S)-Glutamic acid (Glu), which is the main excitatory neurotransmitter in the central nervous
system (CNS), and other excitatory amino acids (EAAs) operate through four different …

This review compares the biological and physiological function of Sigma receptors [σRs] and
their potential therapeutic roles. Sigma receptors are widespread in the central nervous …