Enzymatic halogenation and dehalogenation reactions: pervasive and mechanistically diverse

V Agarwal, ZD Miles, JM Winter, AS Eustáquio… - Chemical …, 2017 - ACS Publications
Naturally produced halogenated compounds are ubiquitous across all domains of life where
they perform a multitude of biological functions and adopt a diversity of chemical structures …

Development of halogenase enzymes for use in synthesis

J Latham, E Brandenburger, SA Shepherd… - Chemical …, 2018 - ACS Publications
Nature has evolved halogenase enzymes to regioselectively halogenate a diverse range of
biosynthetic precursors, with the halogens introduced often having a profound effect on the …

Chemical and genomic characterization of a potential probiotic treatment for stony coral tissue loss disease

B Ushijima, SP Gunasekera, JL Meyer, J Tittl… - Communications …, 2023 - nature.com
Considered one of the most devastating coral disease outbreaks in history, stony coral
tissue loss disease (SCTLD) is currently spreading throughout Florida's coral reefs and the …

Halogenases: a palette of emerging opportunities for synthetic biology–synthetic chemistry and C–H functionalisation

C Crowe, S Molyneux, SV Sharma, Y Zhang… - Chemical Society …, 2021 - pubs.rsc.org
The enzymatic generation of carbon–halogen bonds is a powerful strategy used by both
nature and synthetic chemists to tune the bioactivity, bioavailability and reactivity of …

Current applications of Suzuki–Miyaura coupling reaction in the total synthesis of natural products: an update

A Taheri Kal Koshvandi, MM Heravi… - Applied …, 2018 - Wiley Online Library
Suzuki‐Miyaura Coupling Reaction (SMCR) has been extensively used in the total synthesis
of natural products. We underscored these achievements in a report published in …

Synthesis of nitrogen, phosphorus, selenium and sulfur-containing heterocyclic compounds–determination of their carbonic anhydrase, acetylcholinesterase …

İ Gülçin, B Trofimov, R Kaya, P Taslimi, L Sobenina… - Bioorganic …, 2020 - Elsevier
Abstract Sulfur-containing pyrroles (1–3), tris (2-pyridyl) phosphine (selenide) sulfide (4–5)
and 4-benzyl-6-(thiophen-2-yl) pyrimidin-2-amine (6) were synthesized and characterized …

Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges

V Agarwal, JM Blanton, S Podell, A Taton… - Nature chemical …, 2017 - nature.com
Naturally produced polybrominated diphenyl ethers (PBDEs) pervade the marine
environment and structurally resemble toxic man-made brominated flame retardants. PBDEs …

Triepoxide formation by a flavin-dependent monooxygenase in monensin biosynthesis

Q Wang, N Liu, Y Deng, Y Guan, H **ao… - Nature …, 2023 - nature.com
Monensin A is a prototypical natural polyether polyketide antibiotic. It acts by binding a metal
cation and facilitating its transport across the cell membrane. Biosynthesis of monensin A …

Regio-and stereoselective intermolecular phenol coupling enzymes in secondary metabolite biosynthesis

W Hüttel, M Müller - Natural Product Reports, 2021 - pubs.rsc.org
Covering: 2005 to 2020 Phenol coupling is a key reaction in the biosynthesis of important
biopolymers such as lignin and melanin and of a plethora of biarylic secondary metabolites …

Site-selective C–H halogenation using flavin-dependent halogenases identified via family-wide activity profiling

BF Fisher, HM Snodgrass, KA Jones… - ACS central …, 2019 - ACS Publications
Enzymes are powerful catalysts for site-selective C–H bond functionalization. Identifying
suitable enzymes for this task and for biocatalysis in general remains challenging, however …