Enzymatic halogenation and dehalogenation reactions: pervasive and mechanistically diverse
Naturally produced halogenated compounds are ubiquitous across all domains of life where
they perform a multitude of biological functions and adopt a diversity of chemical structures …
they perform a multitude of biological functions and adopt a diversity of chemical structures …
Development of halogenase enzymes for use in synthesis
J Latham, E Brandenburger, SA Shepherd… - Chemical …, 2018 - ACS Publications
Nature has evolved halogenase enzymes to regioselectively halogenate a diverse range of
biosynthetic precursors, with the halogens introduced often having a profound effect on the …
biosynthetic precursors, with the halogens introduced often having a profound effect on the …
Chemical and genomic characterization of a potential probiotic treatment for stony coral tissue loss disease
Considered one of the most devastating coral disease outbreaks in history, stony coral
tissue loss disease (SCTLD) is currently spreading throughout Florida's coral reefs and the …
tissue loss disease (SCTLD) is currently spreading throughout Florida's coral reefs and the …
Halogenases: a palette of emerging opportunities for synthetic biology–synthetic chemistry and C–H functionalisation
C Crowe, S Molyneux, SV Sharma, Y Zhang… - Chemical Society …, 2021 - pubs.rsc.org
The enzymatic generation of carbon–halogen bonds is a powerful strategy used by both
nature and synthetic chemists to tune the bioactivity, bioavailability and reactivity of …
nature and synthetic chemists to tune the bioactivity, bioavailability and reactivity of …
Current applications of Suzuki–Miyaura coupling reaction in the total synthesis of natural products: an update
A Taheri Kal Koshvandi, MM Heravi… - Applied …, 2018 - Wiley Online Library
Suzuki‐Miyaura Coupling Reaction (SMCR) has been extensively used in the total synthesis
of natural products. We underscored these achievements in a report published in …
of natural products. We underscored these achievements in a report published in …
Synthesis of nitrogen, phosphorus, selenium and sulfur-containing heterocyclic compounds–determination of their carbonic anhydrase, acetylcholinesterase …
Abstract Sulfur-containing pyrroles (1–3), tris (2-pyridyl) phosphine (selenide) sulfide (4–5)
and 4-benzyl-6-(thiophen-2-yl) pyrimidin-2-amine (6) were synthesized and characterized …
and 4-benzyl-6-(thiophen-2-yl) pyrimidin-2-amine (6) were synthesized and characterized …
Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges
Naturally produced polybrominated diphenyl ethers (PBDEs) pervade the marine
environment and structurally resemble toxic man-made brominated flame retardants. PBDEs …
environment and structurally resemble toxic man-made brominated flame retardants. PBDEs …
Triepoxide formation by a flavin-dependent monooxygenase in monensin biosynthesis
Q Wang, N Liu, Y Deng, Y Guan, H **ao… - Nature …, 2023 - nature.com
Monensin A is a prototypical natural polyether polyketide antibiotic. It acts by binding a metal
cation and facilitating its transport across the cell membrane. Biosynthesis of monensin A …
cation and facilitating its transport across the cell membrane. Biosynthesis of monensin A …
Regio-and stereoselective intermolecular phenol coupling enzymes in secondary metabolite biosynthesis
W Hüttel, M Müller - Natural Product Reports, 2021 - pubs.rsc.org
Covering: 2005 to 2020 Phenol coupling is a key reaction in the biosynthesis of important
biopolymers such as lignin and melanin and of a plethora of biarylic secondary metabolites …
biopolymers such as lignin and melanin and of a plethora of biarylic secondary metabolites …
Site-selective C–H halogenation using flavin-dependent halogenases identified via family-wide activity profiling
Enzymes are powerful catalysts for site-selective C–H bond functionalization. Identifying
suitable enzymes for this task and for biocatalysis in general remains challenging, however …
suitable enzymes for this task and for biocatalysis in general remains challenging, however …