Neurodegenerative diseases are characterised by progressive damage to the nervous
system including the selective loss of vulnerable populations of neurons leading to motor …

Activity-dependent changes in the strength of excitatory synapses are a cellular mechanism
for the plasticity of neuronal networks that is widely recognized to underlie cognitive …

Membranes are flexible barriers that surround the cell and its compartments. To execute vital
functions such as locomotion or receptor turnover, cells need to control the shapes of their …

Abstract N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP)
and long-term depression (LTD) of signal transmission form neural circuits and thus are …

Actin filament assembly typically occurs in association with cellular membranes. A large
number of proteins sit at the interface between actin networks and membranes, playing …

Tau is required for the induction of long-term depression (LTD) of synaptic transmission in
the hippocampus. Here we probe the role of tau in LTD, finding that an AMPA receptor …

AMPA-type glutamate receptors (AMPARs) mediate most fast excitatory synaptic
transmission in the brain. Diversity in excitatory signalling arises, in part, from functional …

The development, homeostasis, and regeneration of complex organ systems require
extensive cell–cell communication to ensure that different cells proliferate, migrate …

Among diverse factors regulating excitatory synaptic transmission, the abundance of
postsynaptic glutamate receptors figures prominently in molecular memory and learning …

The brain is programmed to drive behaviour by precisely wiring the appropriate neuronal
circuits. Wiring and rewiring of neuronal circuits largely depends on the orchestrated …