Microfluidics for drug development: from synthesis to evaluation

Y Liu, L Sun, H Zhang, L Shang, Y Zhao - Chemical reviews, 2021 - ACS Publications
Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …

High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

[BOG][B] Culture of animal cells: a manual of basic technique and specialized applications

RI Freshney - 2015 - books.google.com
Since the publication of the sixth edition of this benchmark text, numerous advances in the
field have been made–particularly in stem cells, 3D culture, scale-up, STR profiling, and …

Laser assisted bioprinting of engineered tissue with high cell density and microscale organization

B Guillotin, A Souquet, S Catros, M Duocastella… - Biomaterials, 2010 - Elsevier
Over this decade, cell printing strategy has emerged as one of the promising approaches to
organize cells in two and three dimensional engineered tissues. High resolution and high …

Designing materials to direct stem-cell fate

MP Lutolf, PM Gilbert, HM Blau - Nature, 2009 - nature.com
Proper tissue function and regeneration rely on robust spatial and temporal control of
biophysical and biochemical microenvironmental cues through mechanisms that remain …

Adaptation of high-throughput screening in drug discovery—toxicological screening tests

P Szymański, M Markowicz… - International journal of …, 2011 - mdpi.com
High-throughput screening (HTS) is one of the newest techniques used in drug design and
may be applied in biological and chemical sciences. This method, due to utilization of …

Microfabricated biomaterials for engineering 3D tissues

P Zorlutuna, N Annabi, G Camci‐Unal… - Advanced …, 2012 - Wiley Online Library
Mimicking natural tissue structure is crucial for engineered tissues with intended
applications ranging from regenerative medicine to biorobotics. Native tissues are highly …

Spatially and temporally controlled hydrogels for tissue engineering

J Leijten, J Seo, K Yue, G Trujillo-de Santiago… - Materials Science and …, 2017 - Elsevier
Recent years have seen tremendous advances in the field of hydrogel-based biomaterials.
One of the most prominent revolutions in this field has been the integration of elements or …

Recent advances in multicellular tumor spheroid generation for drug screening

KH Lee, TH Kim - Biosensors, 2021 - mdpi.com
Multicellular tumor spheroids (MCTs) have been employed in biomedical fields owing to
their advantage in designing a three-dimensional (3D) solid tumor model. For controlling …

Beyond annexin V: fluorescence response of cellular membranes to apoptosis

AP Demchenko - Cytotechnology, 2013 - Springer
Dramatic changes in the structure of cell membranes on apoptosis allow easy, sensitive and
non-destructive analysis of this process with the application of fluorescence methods. The …