Does the shape of the electric pulse matter in electroporation?

V Novickij, N Rembiałkowska, W Szlasa… - Frontiers in …, 2022 - frontiersin.org
Electric pulses are widely used in biology, medicine, industry, and food processing.
Numerous studies indicate that electroporation (EP) is a pulse-dependent process, and the …

Electrotherapies for glioblastoma

EPW Jenkins, A Finch, M Gerigk, IF Triantis… - Advanced …, 2021 - Wiley Online Library
Abstract Non‐thermal, intermediate frequency (100–500 kHz) electrotherapies present a
unique therapeutic strategy to treat malignant neoplasms. Here, pulsed electric fields (PEFs) …

Perspective on terahertz applications in bioscience and biotechnology

AG Markelz, DM Mittleman - Acs Photonics, 2022 - ACS Publications
Within the field of terahertz science and technology, one of the most active areas of current
research focuses on the intersection of terahertz measurements and methods with the world …

An ultra-low-cost electroporator with microneedle electrodes (ePatch) for SARS-CoV-2 vaccination

D **a, R **, G Byagathvalli, H Yu, L Ye, CY Lu… - Proceedings of the …, 2021 - pnas.org
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and
other pathogens with pandemic potential requires safe, protective, inexpensive, and easily …

Dynamics of cell death after conventional IRE and H-FIRE treatments

B Mercadal, N Beitel-White, KN Aycock… - Annals of biomedical …, 2020 - Springer
High-frequency irreversible electroporation (H-FIRE) has emerged as an alternative to
conventional irreversible electroporation (IRE) to overcome the issues associated with …

Dynamics of cell death due to electroporation using different pulse parameters as revealed by different viability assays

W Peng, T Polajžer, C Yao, D Miklavčič - Annals of biomedical …, 2024 - Springer
The mechanisms of cell death due to electroporation are still not well understood. Recent
studies suggest that cell death due to electroporation is not an immediate all-or-nothing …

Mitigation of impedance changes due to electroporation therapy using bursts of high-frequency bipolar pulses

SP Bhonsle, CB Arena, DC Sweeney… - Biomedical engineering …, 2015 - Springer
Background For electroporation-based therapies, accurate modeling of the electric field
distribution within the target tissue is important for predicting the treatment volume. In …

An electro-ferroptotic nanoammunition enables image-guided, spatiotemporally controlled cancer ferroptosis induction via irreversible electroporation

JH Han, HS Seo, J Lee, Z Chen, Q Wang… - Chemical Engineering …, 2024 - Elsevier
Ferroptosis, an iron-dependent regulated cell death pathway, has emerged as a promising
modality for cancer therapy. However, current iron-based ferroptosis inducers, which trigger …

Bursts of bipolar microsecond pulses inhibit tumor growth

MB Sano, CB Arena, KR Bittleman, MR DeWitt… - Scientific reports, 2015 - nature.com
Irreversible electroporation (IRE) is an emerging focal therapy which is demonstrating utility
in the treatment of unresectable tumors where thermal ablation techniques are …

A novel high-frequency bipolar pulsed power generator for biological applications

W Zeng, L Yu, S Dong, J Ma, Y Wang… - … on Power Electronics, 2020 - ieeexplore.ieee.org
High-frequency bipolar high-voltage pulsed electric field can be used in tumor ablation to
uniform the electric field distribution in the ablated region and inhibit muscle contraction …