A family of facilitative glucose transporters (GLUTs) is involved in regulating tissue-specific
glucose uptake and metabolism in the liver, skeletal muscle, and adipose tissue to ensure …

When the non-coding repeat expansion in the C9ORF72 gene was discovered to be the
most frequent cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis …

Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …

Macrophages play a pivotal role in tumor immunity. We report that reprogramming of
macrophages to tumor-associated macrophages (TAMs) promotes the secretion of …

Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in
endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is …

Defects in membrane trafficking are hallmarks of neurodegeneration. Rab GTPases are key
regulators of membrane trafficking. Alterations of Rab GTPases, or the membrane …

The Commander complex is required for endosomal recycling of diverse transmembrane
cargos and is mutated in Ritscher-Schinzel syndrome. It comprises two sub-assemblies …

The intronic GGGGCC hexanucleotide repeat expansion in chromosome 9 open reading
frame 72 (C9ORF72) is a prevalent genetic abnormality identified in both frontotemporal …

Birt-Hogg-Dubé syndrome, a human disease characterized by fibrofolliculomas (hair follicle
tumors) as well as a strong predisposition toward the development of pneumothorax …

The organization of cells into interconnected structures such as animal tissues requires a
sophisticated system directing receptors and adhesion proteins to the cell surface. The …