Membrane active antimicrobial peptides: translating mechanistic insights to design

J Li, JJ Koh, S Liu, R Lakshminarayanan… - Frontiers in …, 2017 - frontiersin.org
Antimicrobial peptides (AMPs) are promising next generation antibiotics that hold great
potential for combating bacterial resistance. AMPs can be both bacteriostatic and …

Machine learning and data science in soft materials engineering

AL Ferguson - Journal of Physics: Condensed Matter, 2017 - iopscience.iop.org
In many branches of materials science it is now routine to generate data sets of such large
size and dimensionality that conventional methods of analysis fail. Paradigms and tools from …

Map** membrane activity in undiscovered peptide sequence space using machine learning

EY Lee, BM Fulan, GCL Wong, AL Ferguson - Proceedings of the National …, 2016 - pnas.org
There are some∼ 1,100 known antimicrobial peptides (AMPs), which permeabilize
microbial membranes but have diverse sequences. Here, we develop a support vector …

[HTML][HTML] Role of arginine and lysine in the antimicrobial mechanism of histone-derived antimicrobial peptides

KJ Cutrona, BA Kaufman, DM Figueroa, DE Elmore - FEBS letters, 2015 - Elsevier
Translocation of cell-penetrating peptides is often promoted by increased content of arginine
or other guanidinium groups. However, relatively little research has considered the role of …

Antimicrobial peptides and induced membrane curvature: Geometry, coordination chemistry, and molecular engineering

NW Schmidt, GCL Wong - Current Opinion in Solid State and Materials …, 2013 - Elsevier
Short cationic, amphipathic antimicrobial peptides are multi-functional molecules that have
roles in host defense as direct microbicides and modulators of the immune response. While …

What can machine learning do for antimicrobial peptides, and what can antimicrobial peptides do for machine learning?

EY Lee, MW Lee, BM Fulan, AL Ferguson… - Interface …, 2017 - royalsocietypublishing.org
Antimicrobial peptides (AMPs) are a diverse class of well-studied membrane-permeating
peptides with important functions in innate host defense. In this short review, we provide a …

Effect of hydrophobic groups on antimicrobial and hemolytic activity: Develo** a predictive tool for ternary antimicrobial polymers

PT Phuong, S Oliver, J He, EHH Wong… - …, 2020 - ACS Publications
Antimicrobial polymers have emerged as a potential solution to the growing problem of
antimicrobial resistance. Although several studies have examined the effects of various …

Influenza virus A M2 protein generates negative Gaussian membrane curvature necessary for budding and scission

NW Schmidt, A Mishra, J Wang… - Journal of the …, 2013 - ACS Publications
The M2 protein is a multifunctional protein, which plays several roles in the replication cycle
of the influenza A virus. Here we focus on its ability to promote budding of the mature virus …

[HTML][HTML] The role of spontaneous lipid curvature in the interaction of interfacially active peptides with membranes

D Koller, K Lohner - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2014 - Elsevier
Research on antimicrobial peptides is in part driven by urgent medical needs such as the
steady increase in pathogens being resistant to antibiotics. Despite the wealth of information …

The chemistry and biology of guanidine natural products

RGS Berlinck, S Romminger - Natural Product Reports, 2016 - pubs.rsc.org
Covering: 2012 to 2014. Previous review: Nat. Prod. Rep., 2012, 29, 1382 The present
review discusses the isolation, structure determination, synthesis, biosynthesis and …