[HTML][HTML] Early state research on antifungal natural products

M Negri, TP Salci, CS Shinobu-Mesquita, IRG Capoci… - Molecules, 2014 - mdpi.com
Nosocomial infections caused by fungi have increased greatly in recent years, mainly due to
the rising number of immunocompromised patients. However, the available antifungal …

Insights into the structure and drug design of benzimidazole derivatives targeting the epidermal growth factor receptor (EGFR)

MN Abdullah, Y Ali, S Abd Hamid - Chemical Biology & Drug …, 2022 - Wiley Online Library
Tyrosine kinase overexpression could result in an unfavourable consequence of cancer
progression in the body. A number of kinase inhibitor drugs targeting various cancer‐related …

Synthesis and investigation of novel benzimidazole derivatives as antifungal agents

NT Chandrika, SK Shrestha, HX Ngo… - Bioorganic & medicinal …, 2016 - Elsevier
The rise and emergence of resistance to antifungal drugs by diverse pathogenic fungal
strains have resulted in an increase in demand for new antifungal agents. Various …

Phytochemical analysis, antioxidant, and antimicrobial activities of Jordanian Pomegranate peels

N Sweidan, W Abu Rayyan, I Mahmoud, L Ali - Plos one, 2023 - journals.plos.org
Pomegranate (Punica granatum) peels have shown numerous health benefits such as
antioxidant, anti-inflammatory, and antimicrobial activities. These health activities are owed …

Antifungal drug testing by combining minimal inhibitory concentration testing with target identification by gas chromatography–mass spectrometry

C Müller, U Binder, F Bracher, M Giera - Nature protocols, 2017 - nature.com
Fungal infections and their increasing resistance to antibiotics are an emerging threat to
public health. Novel antifungal drugs, as well technologies that can help us bolster the …

Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion

D Mailänder-Sánchez, C Braunsdorf, C Grumaz… - PloS one, 2017 - journals.plos.org
Candida albicans is an inhabitant of mucosal surfaces in healthy individuals but also the
most common cause of fungal nosocomial blood stream infections, associated with high …

An antifungal benzimidazole derivative inhibits ergosterol biosynthesis and reveals novel sterols

P Keller, C Müller, I Engelhardt, E Hiller… - Antimicrobial agents …, 2015 - journals.asm.org
Fungal infections are a leading cause of morbidity and death for hospitalized patients,
mainly because they remain difficult to diagnose and to treat. Diseases range from …

Synthesis, biological evaluation and mechanistic studies of 4-(1, 3-thiazol-2-yl) morpholine-benzimidazole hybrids as a new structural class of antimicrobials

S Aaghaz, CS Digwal, N Neshat, IK Maurya… - Bioorganic …, 2023 - Elsevier
In spite of several attempts to develop newer pharmacophores as potential antimicrobial
agents, the benzimidazole scaffold is still considered as one of the most sought after …

Design and synthesis of 1‑sec/tert‑butyl-2-chloro/nitrophenylbenzimidazole derivatives: Molecular docking and in vitro evaluation against MDA-MB-231 and MCF-7 …

S Abd Hamid, SM Salhimi, NAS Jalil, M Al-Amin… - Journal of Molecular …, 2023 - Elsevier
Breast cancer is the most common type of cancer among women and the increasing cases
of drug resistance pose a great challenge in the development of new anticancer drugs …

A convenient cellular assay for the identification of the molecular target of ergosterol biosynthesis inhibitors and quantification of their effects on total ergosterol …

C Müller, V Staudacher, J Krauss, M Giera, F Bracher - Steroids, 2013 - Elsevier
Increasing resistance of clinically relevant fungi is causing major problems in anti-mycotic
therapy. Particularly for immunosuppressed patients fungal infections are of concern and …