The case for a renewed focus on Nature in drug discovery is reviewed; not in terms of
natural product screening, but how and why biomimetic molecules, especially those …

Covering: upto 2022 Natural products have an embedded recognition of protein surfaces.
They possess this property as they are produced by biosynthetic enzymes and are …

Small-molecule degraders of disease-driving proteins offer a clinically proven modality with
enhanced therapeutic efficacy and potential to tackle previously undrugged targets. Stable …

Native mass spectrometry (nMS) is one of the most powerful biophysical methods for the
direct observation of noncovalent protein interactions with both small molecules and other …

Native mass spectrometry (nMS) is a biophysical method for studying protein complexes and
can provide insights into subunit stoichiometry and composition, protein–ligand, and protein …

Structural biology offers a versatile arsenal of techniques and methods to investigate the
structure and conformational dynamics of proteins and their assemblies. The growing field of …

Native mass spectrometry (nMS) is becoming a crucial tool for analyzing membrane proteins
(MPs), yet challenges remain in solubilizing and stabilizing their native conformations while …

Highlights•Unravelling the modulation of biochemical pathways by drug candidates.•
Characterising target-small molecule interactions on rapid timescales.•Capturing desirable …

Native mass spectrometry (MS), the analysis of proteins and protein complexes from
solutions that stabilize native solution structures, is a rapidly expanding area. There is strong …

Targeted protein degradation (TPD) is a rapidly expanding field, with various PROTACs
(proteolysis-targeting chimeras) in clinical trials and molecular glues such as …