Pancreatic cancer: Advances and challenges
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
Single-cell profiling to explore pancreatic cancer heterogeneity, plasticity and response to therapy
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer entity characterized by a
heterogeneous genetic landscape and an immunosuppressive tumor microenvironment …
heterogeneous genetic landscape and an immunosuppressive tumor microenvironment …
Epithelial and stromal co-evolution and complicity in pancreatic cancer
SR Hingorani - Nature Reviews Cancer, 2023 - nature.com
Pancreatic ductal adenocarcinomas are distinguished by their robust desmoplasia, or
fibroinflammatory response. Dominated by non-malignant cells, the mutated epithelium must …
fibroinflammatory response. Dominated by non-malignant cells, the mutated epithelium must …
Spatial landscapes of cancers: insights and opportunities
Solid tumours comprise many different cell types organized in spatially structured
arrangements, with substantial intratumour and intertumour heterogeneity. Advances in …
arrangements, with substantial intratumour and intertumour heterogeneity. Advances in …
Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma restrict CD8+ T cell activation and limit responsiveness to immunotherapy in mice
B Assouline, R Kahn, L Hodali, R Condiotti… - Nature …, 2024 - nature.com
Senescent cells within tumors and their stroma exert complex pro-and anti-tumorigenic
functions. However, the identities and traits of these cells, and the potential for improving …
functions. However, the identities and traits of these cells, and the potential for improving …
Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment
The tumor microenvironment (TME) directly determines patients' outcomes and therapeutic
efficiencies. An in‐depth understanding of the TME is required to improve the prognosis of …
efficiencies. An in‐depth understanding of the TME is required to improve the prognosis of …
Tumor immune microenvironment-based therapies in pancreatic ductal adenocarcinoma: time to update the concept
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumors. The tumor
immune microenvironment (TIME) formed by interactions among cancer cells, immune cells …
immune microenvironment (TIME) formed by interactions among cancer cells, immune cells …
Revolutionizing cancer immunotherapy: unleashing the potential of bispecific antibodies for targeted treatment
Recent progressions in immunotherapy have transformed cancer treatment, providing a
promising strategy that activates the immune system of the patient to find and eliminate …
promising strategy that activates the immune system of the patient to find and eliminate …
Single-cell multi-omics analysis of human testicular germ cell tumor reveals its molecular features and microenvironment
Seminoma is the most common malignant solid tumor in 14 to 44 year-old men. However, its
molecular features and tumor microenvironment (TME) is largely unexplored. Here, we …
molecular features and tumor microenvironment (TME) is largely unexplored. Here, we …
[HTML][HTML] Advances in melanoma: from genetic insights to therapeutic innovations
F Valdez-Salazar, LA Jiménez-Del Rio… - Biomedicines, 2024 - mdpi.com
Advances in melanoma research have unveiled critical insights into its genetic and
molecular landscape, leading to significant therapeutic innovations. This review explores the …
molecular landscape, leading to significant therapeutic innovations. This review explores the …