BACKGROUND Biomolecular mechanisms are typically inferred from static structural
“snapshots” obtained by x-ray crystallography, nuclear magnetic resonance (NMR) …

The long-dreamed-of capability of monitoring the molecular machinery in living systems has
not been realized yet, mainly due to the technical limitations of current sensing technologies …

Monitoring and manipulating the physical and chemical behavior of single molecules is an
important development direction of molecular electronics that aids in understanding the …

Single-molecule fluorescence resonance energy transfer (smFRET) is one of the most
general and adaptable single-molecule techniques. Despite the explosive growth in the …

Quantum gases in optical lattices offer an opportunity to experimentally realize and explore
condensed matter models in a clean, tunable system. We used single atom–single lattice …

Fluorescence provides a mechanism for achieving contrast in biological imaging that
enables investigations of molecular structure, dynamics, and function at high spatial and …

Förster Resonance Energy Transfer has served as a molecular ruler that reports
conformational changes and intramolecular distances of single biomolecules,,,. However …

Optical spectroscopy at the ultimate limit of a single molecule has grown over the past dozen
years into a powerful technique for exploring the individual nanoscale behavior of molecules …

The biological and physical sciences share a common interest in small structures (the
definition of'small'depends on the application, but can range from 1 nm to 1 mm). A vigorous …

Nanowire field-effect transistors (NW-FETs) are emerging as powerful sensors for detection
of chemical/biological species with various attractive features including high sensitivity and …