Conspectus Protein biosynthesis is a central process in all living cells that is catalyzed by a
complex molecular machine─ the ribosome. This process is termed translation because the …

Macrolide antibiotics, such as erythromycin, clarithromycin, roxithromycin, and telithromycin,
bind close to the entrance of the ribosomal exit tunnel, adjacent to the peptidyl transferase …

The active site of a Diels− Alderase ribozyme is located in solution by photoaffinity cross-
linking using a productlike azidobenzyl probe. Two key nucleotides are identified that …

This study is directed towards an important problem concerning the organization of the
peptidyl transferase center (PTC) on the mammalian ribosome that cannot be studied by X …

Abstract [eng] The development of next-generation sequencing (NGS) was a revolutionary
milestone in genome analysis. All current sequencing platforms require nucleic acid pre …

Hiermit versichere ich, dass ich die hier vorliegende Arbeit selbst durchgeführt und
eigenständig verfasst habe. Ich habe keine außer den angegebenen Quellen und Hilfsmittel …

The goal of this dissertation is to develop and understand a new method of analysis for RNA:
protein complexes, which will provide differential sequence information to previously …

Nucleic acid and protein complexes play crucial roles in cell functions such as DNA
replication, packaging, repair and transcription and RNA maturation, transport and …