Human health during space travel: state-of-the-art review

C Krittanawong, NK Singh, RA Scheuring, E Urquieta… - Cells, 2022 - mdpi.com
The field of human space travel is in the midst of a dramatic revolution. Upcoming missions
are looking to push the boundaries of space travel, with plans to travel for longer distances …

[HTML][HTML] The NK-92 cell line—30 years later: its impact on natural killer cell research and treatment of cancer

H Klingemann - Cytotherapy, 2023 - Elsevier
The NK-92 cell line, established in 1992, mirrors all the characteristics of highly active blood
natural killer (NK) cells but with much broader and greater cytotoxicity. The cell line was …

Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight

F Wu, H Du, E Overbey, JK Kim, P Makhijani… - Nature …, 2024 - nature.com
Microgravity is associated with immunological dysfunction, though the mechanisms are
poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear …

Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome

AA Voorhies, C Mark Ott, S Mehta, DL Pierson… - Scientific reports, 2019 - nature.com
Over the course of a mission to the International Space Station (ISS) crew members are
exposed to a number of stressors that can potentially alter the composition of their …

Exercise as a countermeasure for latent viral reactivation during long duration space flight

NH Agha, SK Mehta, BV Rooney… - The FASEB …, 2020 - Wiley Online Library
Latent viral reactivation is a commonly reported manifestation of immune system
dysregulation during spaceflight. As physical fitness and exercise training have been shown …

[HTML][HTML] Long-term human spaceflight and inflammaging: Does it promote aging?

M Capri, M Conte, E Ciurca, C Pirazzini… - Ageing research …, 2023 - Elsevier
Spaceflight and its associated stressors, such as microgravity, radiation exposure,
confinement, circadian derailment and disruptive workloads represent an unprecedented …

Microgravity and immune cells

H Lv, H Yang, C Jiang, J Shi… - Journal of the …, 2023 - royalsocietypublishing.org
The microgravity environment experienced during spaceflight severely impaired immune
system, making astronauts vulnerable to various diseases that seriously threaten the health …

Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)

EG Overbey, K Ryon, JK Kim, BT Tierney… - Nature …, 2024 - nature.com
Abstract The SpaceX Inspiration4 mission provided a unique opportunity to study the impact
of spaceflight on the human body. Biospecimen samples were collected from four crew …

Current knowledge about the impact of microgravity on gene regulation

TJ Corydon, H Schulz, P Richter, SM Strauch… - Cells, 2023 - mdpi.com
Microgravity (µ g) has a massive impact on the health of space explorers. Microgravity
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …

Understanding the complexities and changes of the astronaut microbiome for successful long-duration space missions

D Tesei, A Jewczynko, AM Lynch, C Urbaniak - Life, 2022 - mdpi.com
During space missions, astronauts are faced with a variety of challenges that are unique to
spaceflight and that have been known to cause physiological changes in humans over a …