The folding and misfolding of multidomain proteins
S Gianni, M Brunori - Molecular Aspects of Medicine, 2025 - Elsevier
Protein folding represents a vital process for any living organism. While significant insights
have been gained from studying single-domain proteins, our current knowledge on the …
have been gained from studying single-domain proteins, our current knowledge on the …
[HTML][HTML] Structural and Dynamical Properties of Nucleic Acid Hairpins Implicated in Trinucleotide Repeat Expansion Diseases
Dynamic mutations in some human genes containing trinucleotide repeats are associated
with severe neurodegenerative and neuromuscular disorders—known as Trinucleotide (or …
with severe neurodegenerative and neuromuscular disorders—known as Trinucleotide (or …
[HTML][HTML] Erucin, a Natural Isothiocyanate, Prevents Polyglutamine-Induced Toxicity in Caenorhabditis elegans via aak-2/AMPK and daf-16/FOXO Signaling
M Balducci, JT Pérez, CT Del Río, MC Pérez… - International Journal of …, 2024 - mdpi.com
Several neurodegenerative diseases (NDDs), such as Huntington's disease, six of the
spinocerebellar ataxias, dentatorubral-pallidoluysian atrophy, and spinobulbar muscular …
spinocerebellar ataxias, dentatorubral-pallidoluysian atrophy, and spinobulbar muscular …
Role of PQBP1 in Pathogen Recognition—Impact on Innate Immunity
L Wiench, D Rizzo, Z Sinay, Z Nacsa, NV Fuchs… - …, 2024 - pmc.ncbi.nlm.nih.gov
The intrinsically disordered polyglutamine-binding protein 1 (PQBP1) has been linked to
various cellular processes including transcription, alternative splicing, translation and innate …
various cellular processes including transcription, alternative splicing, translation and innate …
Sex and Region-Specific Disruption of Autophagy and Mitophagy in Alzheimer's Disease: Linking Cellular Dysfunction to Cognitive Decline
Macroautophagy and mitophagy are critical processes in Alzheimer disease (AD), yet their
links to behavioral outcomes, particularly sex-specific differences, are not fully understood …
links to behavioral outcomes, particularly sex-specific differences, are not fully understood …
Pushing the limits of structure prediction in regions of disorder using ColabFold: Progress and insights
M Rieth - bioRxiv, 2025 - biorxiv.org
Understanding the impact of amino acid substitutions on protein structure is critical for
unraveling mechanisms of protein function and disease. ColabFold, a user-friendly …
unraveling mechanisms of protein function and disease. ColabFold, a user-friendly …
Molecular Mechanisms of FAN1 in CAG Repeat Instability: Implications for HD and SCAs
B Maring - 2024 - fse.studenttheses.ub.rug.nl
CAG repeat instability is a hallmark of Huntington's disease (HD) and spinocerebellar
ataxias (SCAs), contributing to disease onset and progression through somatic expansions …
ataxias (SCAs), contributing to disease onset and progression through somatic expansions …