The chemistry of heterocycles in the 21st century
VN Charushin, EV Verbitskiy, ON Chupakhin… - Uspekhi Khimii, 2024 - mathnet.ru
The chemistry of heterocyclic compounds has traditionally been and remains a bright area of
chemical science in Russia. This is due to the fact that many heterocycles find the widest …
chemical science in Russia. This is due to the fact that many heterocycles find the widest …
Boron in drug discovery: carboranes as unique pharmacophores in biologically active compounds
F Issa, M Kassiou, LM Rendina - Chemical reviews, 2011 - ACS Publications
Boron, in the form of boric acid, has played a role in medicine as a mild antiseptic and an
eye wash since its preparation from borax in the 18th century. However, the use of boron in …
eye wash since its preparation from borax in the 18th century. However, the use of boron in …
The many faces of the adamantyl group in drug design
J Liu, D Obando, V Liao, T Lifa, R Codd - European journal of medicinal …, 2011 - Elsevier
Adamantyl-based compounds are used clinically for the treatment of neurological
conditions, as anti-viral agents and as agents against type 2 diabetes. The value of the …
conditions, as anti-viral agents and as agents against type 2 diabetes. The value of the …
Propargylamine as functional moiety in the design of multifunctional drugs for neurodegenerative disorders: MAO inhibition and beyond
Much progress has been made in designing analogues that can potentially confer
neuroprotection against debilitating neurodegenerative disorders, yet the multifactorial …
neuroprotection against debilitating neurodegenerative disorders, yet the multifactorial …
Polycyclic cage structures as lipophilic scaffolds for neuroactive drugs
Polycyclic cage scaffolds have been successfully used in the development of numerous lead
compounds demonstrating activity in the central nervous system (CNS). Several …
compounds demonstrating activity in the central nervous system (CNS). Several …
Rationally designed multi-targeted agents against neurodegenerative diseases
WJ Geldenhuys… - Current medicinal …, 2013 - ingentaconnect.com
Neurodegenerative diseases are complex disorders with several pathoetiological pathways
leading to cell death. Rationally designed multi-targeted agents, or “multi-targeted designed …
leading to cell death. Rationally designed multi-targeted agents, or “multi-targeted designed …
Antiviral properties of cage compounds. New prospects
YN Klimochkin, VA Shiryaev, MV Leonova - Russian Chemical Bulletin, 2015 - Springer
The published data of the last 15 years on the antiviral activity and the mechanism of action
of cage compounds are integrated and described systematically. The considerable interest …
of cage compounds are integrated and described systematically. The considerable interest …
Molecular Acrobatics in Polycyclic Frames: Synthesis of “Kurmanediol” via Post-synthetic Modification of Cage Molecules by Olefinic Metathesis
S Kotha, G Mehta - The Journal of Organic Chemistry, 2023 - ACS Publications
We report late-stage ring-opening metathesis (ROM), ring-rearrangement metathesis (RRM),
and ring-closing metathesis (RCM) approaches to generate expanded pentacycloundecane …
and ring-closing metathesis (RCM) approaches to generate expanded pentacycloundecane …
Review on plasmas in extraordinary media: plasmas in cryogenic conditions and plasmas in supercritical fluids
Plasma science and technology has enabled advances in very diverse fields: micro-and
nanotechnology, chemical synthesis, materials fabrication and, more recently, biotechnology …
nanotechnology, chemical synthesis, materials fabrication and, more recently, biotechnology …
Multifunctional drugs with different CNS targets for neuropsychiatric disorders
CJ Van der Schyf, WJ Geldenhuys… - Journal of …, 2006 - Wiley Online Library
The multiple disease etiologies that lead to neuropsychiatric disorders, such as Parkinson's
and Alzheimer's disease, amyotrophic lateral sclerosis, Huntington disease, schizophrenia …
and Alzheimer's disease, amyotrophic lateral sclerosis, Huntington disease, schizophrenia …