The chemistry of heterocycles in the 21st century

VN Charushin, EV Verbitskiy, ON Chupakhin… - Uspekhi Khimii, 2024 - mathnet.ru
The chemistry of heterocyclic compounds has traditionally been and remains a bright area of
chemical science in Russia. This is due to the fact that many heterocycles find the widest …

Boron in drug discovery: carboranes as unique pharmacophores in biologically active compounds

F Issa, M Kassiou, LM Rendina - Chemical reviews, 2011 - ACS Publications
Boron, in the form of boric acid, has played a role in medicine as a mild antiseptic and an
eye wash since its preparation from borax in the 18th century. However, the use of boron in …

The many faces of the adamantyl group in drug design

J Liu, D Obando, V Liao, T Lifa, R Codd - European journal of medicinal …, 2011 - Elsevier
Adamantyl-based compounds are used clinically for the treatment of neurological
conditions, as anti-viral agents and as agents against type 2 diabetes. The value of the …

Propargylamine as functional moiety in the design of multifunctional drugs for neurodegenerative disorders: MAO inhibition and beyond

FT Zindo, J Joubert, SF Malan - Future medicinal chemistry, 2015 - Taylor & Francis
Much progress has been made in designing analogues that can potentially confer
neuroprotection against debilitating neurodegenerative disorders, yet the multifactorial …

Polycyclic cage structures as lipophilic scaffolds for neuroactive drugs

J Joubert, WJ Geldenhuys, CJ Van der Schyf… - …, 2012 - Wiley Online Library
Polycyclic cage scaffolds have been successfully used in the development of numerous lead
compounds demonstrating activity in the central nervous system (CNS). Several …

Rationally designed multi-targeted agents against neurodegenerative diseases

WJ Geldenhuys… - Current medicinal …, 2013 - ingentaconnect.com
Neurodegenerative diseases are complex disorders with several pathoetiological pathways
leading to cell death. Rationally designed multi-targeted agents, or “multi-targeted designed …

Antiviral properties of cage compounds. New prospects

YN Klimochkin, VA Shiryaev, MV Leonova - Russian Chemical Bulletin, 2015 - Springer
The published data of the last 15 years on the antiviral activity and the mechanism of action
of cage compounds are integrated and described systematically. The considerable interest …

Molecular Acrobatics in Polycyclic Frames: Synthesis of “Kurmanediol” via Post-synthetic Modification of Cage Molecules by Olefinic Metathesis

S Kotha, G Mehta - The Journal of Organic Chemistry, 2023 - ACS Publications
We report late-stage ring-opening metathesis (ROM), ring-rearrangement metathesis (RRM),
and ring-closing metathesis (RCM) approaches to generate expanded pentacycloundecane …

Review on plasmas in extraordinary media: plasmas in cryogenic conditions and plasmas in supercritical fluids

S Stauss, H Muneoka, K Terashima - Plasma Sources Science …, 2018 - iopscience.iop.org
Plasma science and technology has enabled advances in very diverse fields: micro-and
nanotechnology, chemical synthesis, materials fabrication and, more recently, biotechnology …

Multifunctional drugs with different CNS targets for neuropsychiatric disorders

CJ Van der Schyf, WJ Geldenhuys… - Journal of …, 2006 - Wiley Online Library
The multiple disease etiologies that lead to neuropsychiatric disorders, such as Parkinson's
and Alzheimer's disease, amyotrophic lateral sclerosis, Huntington disease, schizophrenia …